Literature DB >> 23117910

Dexmedetomidine to treat lisdexamfetamine overdose and serotonin toxidrome in a 6-year-old girl.

Olugbenga A Akingbola1, Dinesh Singh.   

Abstract

A 6-year-old girl displayed symptoms of serotonin syndrome after accidental ingestion of Vyvanse (lisdexamfetamine dimesylate). Dexmedetomidine was administered because of persistent neuromuscular hyperactivity and severe agitation despite initial therapy with benzodiazepines. Some children show a paradoxical reaction to benzodiazepines, and dexmedetomidine has a possible role in the treatment of serotonin syndrome.

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Year:  2012        PMID： 23117910     DOI： 10.4037/ajcc2012768

Source DB:  PubMed          Journal:  Am J Crit Care        ISSN： 1062-3264            Impact factor:   2.228


  10 in total

1.  An Infant with a Prolonged Sympathomimetic Toxidrome after Lisdexamfetamine Dimesylate Ingestion.

Authors:  Kelly E Wood; Matthew D Krasowski
Journal:  J Med Toxicol       Date:  2016-06-08

2.  Dexmedetomidine for acute baclofen withdrawal.

Authors:  Simon Morr; Christopher M Heard; Veetai Li; Renée M Reynolds
Journal:  Neurocrit Care       Date:  2015-04       Impact factor: 3.210

3.  Dexmedetomidine to control signs associated with lisdexamfetamine dimesylate toxidrome in a cat.

Authors:  Christopher L Norkus; Iain Keir; Charlotte Means
Journal:  Can Vet J       Date:  2017-03       Impact factor: 1.008

4.  Dexmedetomidine to Treat 3, 4-Methylenedioxymethamphetamine-Induced Agitation in a 13-Month-Old Infant: A Case Report and Literature Review.

Authors:  Patricia J L T Sanders; Jan Hanot
Journal:  J Pediatr Intensive Care       Date:  2019-02-13

5.  A comparison of midazolam and dexmedetomidine for the recovery of serotonin syndrome in rats.

Authors:  Takashi Kawano; Tetsuya Takahashi; Satomi Kaminaga; Takao Kadono; Daiki Yamanaka; Hideki Iwata; Satoru Eguchi; Masataka Yokoyama
Journal:  J Anesth       Date:  2015-01-18       Impact factor: 2.078

6.  Dexmedetomidine Infusion to Control Agitation due to Anticholinergic Toxidromes in Adolescents, a Case Series.

Authors:  Samantha W Gee; Ada Lin; Joseph D Tobias
Journal:  J Pediatr Pharmacol Ther       Date:  2015 Jul-Aug

Review 7.  Overdose of drugs for attention-deficit hyperactivity disorder: clinical presentation, mechanisms of toxicity, and management.

Authors:  Henry A Spiller; Hannah L Hays; Alfred Aleguas
Journal:  CNS Drugs       Date:  2013-07       Impact factor: 5.749

Review 8.  A systematic review of the safety of lisdexamfetamine dimesylate.

Authors:  David R Coghill; Beatriz Caballero; Shaw Sorooshian; Richard Civil
Journal:  CNS Drugs       Date:  2014-06       Impact factor: 5.749

9.  A case series involving young children presenting with accidental ingestion of amphetamine based stimulants.

Authors:  Kelly E Wood; Patrick J McCarthy; Matthew D Krasowski
Journal:  Toxicol Rep       Date:  2018-11-03

10.  The Role of Dexmedetomidine in Pediatric Patients Presenting with an Anticholinergic Toxidrome.

Authors:  Mitchell Zekhtser; Erin Carroll; Molly Boyd; Shashikanth Ambati
Journal:  Case Rep Crit Care       Date:  2021-08-28
  10 in total

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