Literature DB >> 23117821

Akt1, EMSY, BRCA2 and type I IFN signaling: a novel arm of the IFN response.

Scott A Ezell1, Philip N Tsichlis.   

Abstract

Interferon-stimulated transcription is thought to occur mainly through the action of the JAK/STAT pathway. However, recent findings revealed an additional PI3K/Akt-dependent pathway, which contributes to the induction of a set of interferon-stimulated genes (ISGs) through the regulation of the transcriptional repressor EMSY.

Entities:  

Keywords:  Akt; BRCA2; EMSY; IRF9; ISRE; JAK/STAT pathway; interferon-stimulated gene (ISG)

Mesh：

Substances：

Year:  2012        PMID： 23117821      PMCID： PMC3630186          DOI： 10.4161/trns.21904

Source DB:  PubMed          Journal:  Transcription        ISSN： 2154-1272


  42 in total

1.  Induction of interferon-stimulated gene expression and antiviral responses require protein deacetylase activity.

Authors:  Hao-Ming Chang; Matthew Paulson; Michelle Holko; Charles M Rice; Bryan R G Williams; Isabelle Marié; David E Levy
Journal:  Proc Natl Acad Sci U S A       Date:  2004-06-21       Impact factor: 11.205

2.  Arginine methylation of STAT1: a reassessment.

Authors:  Torsten Meissner; Eberhard Krause; Inga Lödige; Uwe Vinkemeier
Journal:  Cell       Date:  2004-11-24       Impact factor: 41.582

Review 3.  Alternative signaling pathways regulating type I interferon-induced apoptosis.

Authors:  Katja Pokrovskaja; Theocharis Panaretakis; Dan Grandér
Journal:  J Interferon Cytokine Res       Date:  2005-12       Impact factor: 2.607

4.  Overexpression of IFITM1 has clinicopathologic effects on gastric cancer and is regulated by an epigenetic mechanism.

Authors:  Jieun Lee; Sung-Ho Goh; Naaleum Song; Jung-Ah Hwang; Seungyoon Nam; Il Ju Choi; Aesun Shin; In-Hoo Kim; Mi-Ha Ju; Jin Sook Jeong; Yeon-Su Lee
Journal:  Am J Pathol       Date:  2012-05-18       Impact factor: 4.307

5.  Arginine methylation of STAT1 modulates IFNalpha/beta-induced transcription.

Authors:  K A Mowen; J Tang; W Zhu; B T Schurter; K Shuai; H R Herschman; M David
Journal:  Cell       Date:  2001-03-09       Impact factor: 41.582

6.  Are STATS arginine-methylated?

Authors:  Waraporn Komyod; Uta-Maria Bauer; Peter C Heinrich; Serge Haan; Iris Behrmann
Journal:  J Biol Chem       Date:  2005-04-12       Impact factor: 5.157

7.  Down-regulation of UCRP and UBE2L6 in BRCA2 knocked-down human breast cells.

Authors:  Manish K Tripathi; Gautam Chaudhuri
Journal:  Biochem Biophys Res Commun       Date:  2005-03-04       Impact factor: 3.575

8.  Interactions between STAT and non-STAT proteins in the interferon-stimulated gene factor 3 transcription complex.

Authors:  C M Horvath; G R Stark; I M Kerr; J E Darnell
Journal:  Mol Cell Biol       Date:  1996-12       Impact factor: 4.272

9.  EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer.

Authors:  Luke Hughes-Davies; David Huntsman; Margarida Ruas; Francois Fuks; Jacqueline Bye; Suet-Feung Chin; Jonathon Milner; Lindsay A Brown; Forrest Hsu; Blake Gilks; Torsten Nielsen; Michael Schulzer; Stephen Chia; Joseph Ragaz; Anthony Cahn; Lori Linger; Hilal Ozdag; Elena Cattaneo; E S Jordanova; Edward Schuuring; David S Yu; Ashok Venkitaraman; Bruce Ponder; Aidan Doherty; Samuel Aparicio; David Bentley; Charles Theillet; Chris P Ponting; Carlos Caldas; Tony Kouzarides
Journal:  Cell       Date:  2003-11-26       Impact factor: 41.582

10.  Cooperation of Stat2 and p300/CBP in signalling induced by interferon-alpha.

Authors:  S Bhattacharya; R Eckner; S Grossman; E Oldread; Z Arany; A D'Andrea; D M Livingston
Journal:  Nature       Date:  1996-09-26       Impact factor: 49.962
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  7 in total

1.  EMSY promoted the growth and migration of ovarian cancer cells.

Authors:  Xiaohong Zhao; Yan Zhou; Mingchao Nie; Saiqiong Xian; Huli Chen; Yingmei Wen; Linjing Zhang; Yumin Huang; Mingfa Chen; Shaosheng Wang
Journal:  Tumour Biol       Date:  2014-12-16

2.  EMSY inhibits homologous recombination repair and the interferon response, promoting lung cancer immune evasion.

Authors:  Antonio Marzio; Emma Kurz; Jennifer M Sahni; Giuseppe Di Feo; Joseph Puccini; Shaowen Jiang; Carolina Alcantara Hirsch; Arnaldo A Arbini; Warren L Wu; Harvey I Pass; Dafna Bar-Sagi; Thales Papagiannakopoulos; Michele Pagano
Journal:  Cell       Date:  2021-12-27       Impact factor: 41.582

3.  Multiethnic genome-wide and HLA association study of total serum IgE level.

Authors:  Michelle Daya; Corey Cox; Nathalie Acevedo; Meher P Boorgula; Monica Campbell; Sameer Chavan; Michael H Cho; Gloria L David; Priyadarshini Kachroo; Jessica Lasky-Su; Xingnan Li; Caitlin P McHugh; Dandi Qiao; Nicholas Rafaels; Lisa A Beck; Eugene R Bleecker; Luis Caraballo; Adrienne L Cupples; Camila A Figueiredo; Richard L Gallo; Jon Hanifin; Nadia N Hansel; Tissa R Hata; Craig P Hersh; Jennifer Knight-Madden; Donald Y M Leung; Emma Guttman-Yassky; Deborah A Meyers; George O'Connor; Carole Ober; Peck Y Ong; Victor E Ortega; Amy S Paller; Nirupama Putcha; Robert M Reed; Lynda C Schneider; Edwin K Silverman; Mark K Slifka; Jonathan M Spergel; Ramachandran S Vasan; Karine A Viaud-Martinez; Harold Watson; Scott T Weiss; Ingo Ruczinski; Terri H Beaty; Rasika A Mathias; Kathleen C Barnes
Journal:  J Allergy Clin Immunol       Date:  2021-09-15       Impact factor: 10.793

4.  Clinical importance of the EMSY gene expression and polymorphisms in ovarian cancer.

Authors:  Agnieszka Dansonka-Mieszkowska; Lukasz M Szafron; Joanna Moes-Sosnowska; Mariusz Kulinczak; Anna Balcerak; Bozena Konopka; Magdalena Kulesza; Agnieszka Budzilowska; Martyna Lukasik; Urszula Piekarska; Iwona K Rzepecka; Joanna Parada; Renata Zub; Barbara Pienkowska-Grela; Radoslaw Madry; Jan K Siwicki; Jolanta Kupryjanczyk
Journal:  Oncotarget       Date:  2018-04-03

Review 5.  New Insights into Protein Kinase B/Akt Signaling: Role of Localized Akt Activation and Compartment-Specific Target Proteins for the Cellular Radiation Response.

Authors:  Klaudia Szymonowicz; Sebastian Oeck; Nathalie M Malewicz; Verena Jendrossek
Journal:  Cancers (Basel)       Date:  2018-03-18       Impact factor: 6.639

6.  Blocking the PI3K/AKT pathway enhances mammalian reovirus replication by repressing IFN-stimulated genes.

Authors:  Jin Tian; Xiaozhan Zhang; Hongxia Wu; Chunguo Liu; Zhijie Li; Xiaoliang Hu; Shuo Su; Lin-Fa Wang; Liandong Qu
Journal:  Front Microbiol       Date:  2015-09-02       Impact factor: 5.640

7.  Transcriptome Profiling Reveals Disruption of Innate Immunity in Chronic Heavy Ethanol Consuming Female Rhesus Macaques.

Authors:  Suhas Sureshchandra; Maham Rais; Cara Stull; Kathleen Grant; Ilhem Messaoudi
Journal:  PLoS One       Date:  2016-07-18       Impact factor: 3.240
  7 in total

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