Literature DB >> 23117521

PET/SPECT imaging of hindlimb ischemia: focusing on angiogenesis and blood flow.

Hakan Orbay1, Hao Hong, Yin Zhang, Weibo Cai.   

Abstract

Peripheral artery disease (PAD) is a result of the atherosclerotic narrowing of blood vessels to the extremities, and the subsequent tissue ischemia can lead to the up-regulation of angiogenic growth factors and formation of new vessels as a recovery mechanism. Such formation of new vessels can be evaluated with various non-invasive molecular imaging techniques, where serial images from the same subjects can be obtained to allow the documentation of disease progression and therapeutic response. The most commonly used animal model for preclinical studies of PAD is the murine hindlimb ischemia model, and a number of radiotracers have been investigated for positron emission tomography (PET) and single photon emission computed tomography (SPECT) imaging of PAD. In this review article, we summarize the PET/SPECT tracers that have been tested in the murine hindlimb ischemia model as well as those used clinically to assess the extremity blood flow.

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Year:  2012        PMID： 23117521      PMCID： PMC3596452          DOI： 10.1007/s10456-012-9319-4

Source DB:  PubMed          Journal:  Angiogenesis        ISSN： 0969-6970            Impact factor:   9.596


  76 in total

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8.  Monitoring of the biological response to murine hindlimb ischemia with 64Cu-labeled vascular endothelial growth factor-121 positron emission tomography.

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2.  ImmunoPET of CD146 in a Murine Hindlimb Ischemia Model.

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7.  Pravastatin stimulates angiogenesis in a murine hindlimb ischemia model: a positron emission tomography imaging study with (64)Cu-NOTA-TRC105.

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8.  Positron emission tomography imaging of angiogenesis in a murine hindlimb ischemia model with 64Cu-labeled TRC105.

Authors:  Hakan Orbay; Yin Zhang; Hao Hong; Timothy A Hacker; Hector F Valdovinos; James A Zagzebski; Charles P Theuer; Todd E Barnhart; Weibo Cai
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