Literature DB >> 2311718

Inhibitory effects of spermine and spermidine on muscle calpain II.

P Johnson1, J L Hammer.   

Abstract

The muscle enzyme calpain II, in contrast to muscle calpain I, was markedly inhibited by millimolar concentrations of the polyamines spermine and spermidine. These compounds and the calpain inhibitor calpastatin had synergistic inhibitory effects on calpain II. These results suggest that the polyamines may have possible regulatory effects on the in vivo activity of calpain II enzymes.

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Year:  1990        PMID： 2311718     DOI： 10.1007/bf01951764

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  12 in total

1.  Cross-reactivity of a monoclonal antibody to the catalytic subunit of chicken gizzard desmin-specific calpain.

Authors:  J H Aldstadt; M J Allen; P Johnson
Journal:  Comp Biochem Physiol B       Date:  1986

2.  Effect of alpha-difluoromethylornithine on polyamine and DNA synthesis in regenerating rat liver: reversal of inhibition of DNA synthesis by putrescine.

Authors:  H Pösö; A E Pegg
Journal:  Biochim Biophys Acta       Date:  1982-02-26

3.  Calmodulin and protein kinase C antagonists also inhibit the Ca2+-dependent protein protease, calpain I.

Authors:  L M Brumley; R W Wallace
Journal:  Biochem Biophys Res Commun       Date:  1989-03-31       Impact factor: 3.575

4.  Inhibition of cyclic nucleotide phosphodiesterase and calcineurin by spermine, a calcium-independent calmodulin antagonist.

Authors:  J D Walters; J D Johnson
Journal:  Biochim Biophys Acta       Date:  1988-11-02

5.  Polyamines appear to be second messengers in mediating Ca2+ fluxes and neurotransmitter release in potassium-depolarized synaptosomes.

Authors:  Z Iqbal; H Koenig
Journal:  Biochem Biophys Res Commun       Date:  1985-12-17       Impact factor: 3.575

6.  Polyamines inhibit phospholipid-sensitive and calmodulin-sensitive Ca2+-dependent protein kinases.

Authors:  D F Qi; R C Schatzman; G J Mazzei; R S Turner; R L Raynor; S Liao; J F Kuo
Journal:  Biochem J       Date:  1983-08-01       Impact factor: 3.857

7.  Beta-adrenergic stimulation of Ca2+ fluxes, endocytosis, hexose transport, and amino acid transport in mouse kidney cortex is mediated by polyamine synthesis.

Authors:  H Koenig; A D Goldstone; C Y Lu
Journal:  Proc Natl Acad Sci U S A       Date:  1983-12       Impact factor: 11.205

8.  Calpain and calpastatin levels in dystrophic hamster skeletal muscles.

Authors:  P Johnson; J L Hammer
Journal:  Int J Biochem       Date:  1988

9.  Calpain inhibition by peptide epoxides.

Authors:  C Parkes; A A Kembhavi; A J Barrett
Journal:  Biochem J       Date:  1985-09-01       Impact factor: 3.857

Review 10.  Calcium-dependent proteinases and specific inhibitors: calpain and calpastatin.

Authors:  T Murachi
Journal:  Biochem Soc Symp       Date:  1984
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  1 in total

1.  Effects of polyamine levels on the degradation of short-lived and long-lived proteins in cultured L-132 human lung cells.

Authors:  D Corella; M Guillén; J M Hernández; J Hernández-Yago
Journal:  Biochem J       Date:  1998-09-01       Impact factor: 3.857
  1 in total

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