PURPOSE: To assess by magnetic resonance imaging (MRI) if adult non-cultivated bone marrow stem cells accelerate tendon-to-bone healing in the femoral tunnel, after hamstring anterior cruciate ligament (ACL) reconstruction. METHODS:Forty-three patients underwentACL reconstruction and were prospectively randomized into two groups: 20 patients in the experimental group (group A) with adult non-cultivated bone marrow stem cells and 23 patients in the control group (group B) without adult non-cultivated bone marrow stem cells. All patients underwent MRI of the knee at three months after surgery to evaluate the signal-to-noise ratio of the interzone. RESULTS: There was no difference in the signal-to-noise ratio of the interzone on MRI between the experimental and the control group. CONCLUSIONS: Adult non-cultivated bone marrow stem cells do not seem to accelerate graft-to-bone healing in ACL reconstruction. The clinical relevance of this finding is that adult non-cultivated bone marrow stem cells apparently have a limited role in ACL reconstruction.
RCT Entities:
PURPOSE: To assess by magnetic resonance imaging (MRI) if adult non-cultivated bone marrow stem cells accelerate tendon-to-bone healing in the femoral tunnel, after hamstring anterior cruciate ligament (ACL) reconstruction. METHODS: Forty-three patients underwent ACL reconstruction and were prospectively randomized into two groups: 20 patients in the experimental group (group A) with adult non-cultivated bone marrow stem cells and 23 patients in the control group (group B) without adult non-cultivated bone marrow stem cells. All patients underwent MRI of the knee at three months after surgery to evaluate the signal-to-noise ratio of the interzone. RESULTS: There was no difference in the signal-to-noise ratio of the interzone on MRI between the experimental and the control group. CONCLUSIONS: Adult non-cultivated bone marrow stem cells do not seem to accelerate graft-to-bone healing in ACL reconstruction. The clinical relevance of this finding is that adult non-cultivated bone marrow stem cells apparently have a limited role in ACL reconstruction.
Authors: Volker Musahl; Ehab M Nazzal; Gian Andrea Lucidi; Rafael Serrano; Jonathan D Hughes; Fabrizio Margheritini; Stefano Zaffagnini; Freddie H Fu; Jon Karlsson Journal: Knee Surg Sports Traumatol Arthrosc Date: 2021-12-20 Impact factor: 4.342
Authors: Berardo Di Matteo; Markus Loibl; Luca Andriolo; Giuseppe Filardo; Johannes Zellner; Matthias Koch; Peter Angele Journal: World J Orthop Date: 2016-09-18