Literature DB >> 23116944

A unique host defense pathway: TRIF mediates both antiviral and antibacterial immune responses.

Jinhee Hyun1, Saravana Kanagavelu, Masayuki Fukata.   

Abstract

Both anti-viral and anti-bacterial host defense mechanisms involve TRIF signaling. TRIF provides early clearance of pathogens and coordination of a local inflammatory ensemble through an interferon cascade, while it may trigger organ damage. The multipotentiality of TRIF-mediated immune machinery may direct the fate of our continuous battle with microbes.
Copyright © 2012 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.

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Year:  2012        PMID: 23116944      PMCID: PMC3537922          DOI: 10.1016/j.micinf.2012.10.011

Source DB:  PubMed          Journal:  Microbes Infect        ISSN: 1286-4579            Impact factor:   2.700


  72 in total

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