OBJECTIVE: To compare the levels of urinary excretion of nephrin in women experiencing either normotensive or severe preeclamptic pregnancies, and to examine the relationship between urinary nephrin levels and clinical parameters of preeclampsia. STUDY DESIGN: In a case control study we collected serum and urine specimens from women with normal pregnancy (n=30) and from women with severe preeclampsia (n=43). Serum nephrin levels and urinary nephrin concentrations were measured in all patients. RESULTS: Both serum and urine concentrations of nephrin were significantly higher in the severe preeclamptic group than in the normal pregnancy group. In addition, we identified a significant relationship between urinary nephrin levels and urine protein concentrations in the severe preeclamptic group. Urine nephrin concentrations were also correlated with serum creatinine levels and with diastolic blood pressure in the severe preeclamptic group. CONCLUSION: The positive correlations observed in this study suggest that urinary nephrin excretion might play an important role in the pathogenesis of proteinuria during preeclampsia and could be a good indicator of renal damage.
OBJECTIVE: To compare the levels of urinary excretion of nephrin in women experiencing either normotensive or severe preeclamptic pregnancies, and to examine the relationship between urinary nephrin levels and clinical parameters of preeclampsia. STUDY DESIGN: In a case control study we collected serum and urine specimens from women with normal pregnancy (n=30) and from women with severe preeclampsia (n=43). Serum nephrin levels and urinary nephrin concentrations were measured in all patients. RESULTS: Both serum and urine concentrations of nephrin were significantly higher in the severe preeclamptic group than in the normal pregnancy group. In addition, we identified a significant relationship between urinary nephrin levels and urine protein concentrations in the severe preeclamptic group. Urine nephrin concentrations were also correlated with serum creatinine levels and with diastolic blood pressure in the severe preeclamptic group. CONCLUSION: The positive correlations observed in this study suggest that urinary nephrin excretion might play an important role in the pathogenesis of proteinuria during preeclampsia and could be a good indicator of renal damage.
Authors: Sarwat I Gilani; Ulrik Dolberg Anderson; Muthuvel Jayachandran; Tracey L Weissgerber; Ladan Zand; Wendy M White; Natasa Milic; Maria Lourdes Gonzalez Suarez; Rangit Reddy Vallapureddy; Åsa Nääv; Lena Erlandsson; John C Lieske; Joseph P Grande; Karl A Nath; Stefan R Hansson; Vesna D Garovic Journal: J Am Soc Nephrol Date: 2017-07-20 Impact factor: 10.121
Authors: Gilberto Kac; Roberta H Mendes; Dayana R Farias; Ilana Eshriqui; Fernanda Rebelo; Camila Benaim; Ana Amélia F Vilela; Natália S Lima; Wilza A F Peres; Gil F Salles Journal: Medicine (Baltimore) Date: 2015-05 Impact factor: 1.889
Authors: Wendy M White; Angelica T Garrett; Iasmina M Craici; Steven J Wagner; Patrick D Fitz-Gibbon; Kim A Butters; Brian C Brost; Carl H Rose; Joseph P Grande; Vesna D Garovic Journal: PLoS One Date: 2014-03-24 Impact factor: 3.240
Authors: Iasmina M Craici; Steven J Wagner; Tracey L Weissgerber; Joseph P Grande; Vesna D Garovic Journal: Kidney Int Date: 2014-02-26 Impact factor: 10.612