| Literature DB >> 23116064 |
Anna D Fotiadou1, Alexandros L Zografos.
Abstract
Application of a tandem Knoevenagel/6π-electrocyclization sequence is able to produce highly substituted pyranopyridones from moderate to high yields in a one-step reaction. High diasteroselectivity is observed in some cases and was rationalized on the basis of the thermodynamic control of the evidenced reversibility of a 6π-electrocyclization reaction. Numerous examples are provided establishing a novel entry in natural product-like structures of pyranopyridone alkaloids.Entities:
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Year: 2012 PMID： 23116064 DOI： 10.1021/ol3026457
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005