OBJECTIVE: Childhood obesity is associated with an increased risk for atherosclerosis mediated by the pathogenetic mechanisms that lead to the development of the Metabolic Syndrome (MetS). High-Sensitivity Troponin T (hs-TnT) is a specific marker of ischemic myocardial damage, whereas a minimal elevation of this biomarker has been found in adults with a high-risk for cardiovascular disease. We hypothesized that hs-TnT might be altered in obese children with and/or without the Mets. MATERIALS AND METHODS: Fifty-seven (34 males) obese and 25 non-obese (6 males) children were assessed at the Childhood Obesity Clinic of our department. Obesity was defined using the IOTF criteria. Metabolic syndrome was defined with the IDF criteria. Hs-TnT was measured using an electrochemiluminescence-based assay. RESULTS: The entire group of obese children had significantly higher hs-TnT concentrations [4.1 ± 3.4 ng/L] (p=0.029) than the non-obese ones [3.0 ± 0.2 ng/L), however, in both groups the levels of the cardiac biomarker were within the normal range. Comparison of the obese children with or without the MetS and the non-obese, revealed that those with the MetS had significantly higher hs-TnT (6.7±7.1 ng/L) than the obese without MetS (3.7 ± 2.1 ng/L) [p=0.044], and the non-obese [p=0.014]. Hs-TnT did not differ between the obese without MetS and the non-obese. CONCLUSIONS: Circulating concentrations of hs-TnT in obese children with the MetS are higher than those of the obese without the MetS and the non-obese, suggesting that it is obesity-related metabolic changes rather than obesity per se linked to increased hs-TnT in children.
OBJECTIVE: Childhood obesity is associated with an increased risk for atherosclerosis mediated by the pathogenetic mechanisms that lead to the development of the Metabolic Syndrome (MetS). High-Sensitivity Troponin T (hs-TnT) is a specific marker of ischemic myocardial damage, whereas a minimal elevation of this biomarker has been found in adults with a high-risk for cardiovascular disease. We hypothesized that hs-TnT might be altered in obesechildren with and/or without the Mets. MATERIALS AND METHODS: Fifty-seven (34 males) obese and 25 non-obese (6 males) children were assessed at the Childhood Obesity Clinic of our department. Obesity was defined using the IOTF criteria. Metabolic syndrome was defined with the IDF criteria. Hs-TnT was measured using an electrochemiluminescence-based assay. RESULTS: The entire group of obesechildren had significantly higher hs-TnT concentrations [4.1 ± 3.4 ng/L] (p=0.029) than the non-obese ones [3.0 ± 0.2 ng/L), however, in both groups the levels of the cardiac biomarker were within the normal range. Comparison of the obesechildren with or without the MetS and the non-obese, revealed that those with the MetS had significantly higher hs-TnT (6.7±7.1 ng/L) than the obese without MetS (3.7 ± 2.1 ng/L) [p=0.044], and the non-obese [p=0.014]. Hs-TnT did not differ between the obese without MetS and the non-obese. CONCLUSIONS: Circulating concentrations of hs-TnT in obesechildren with the MetS are higher than those of the obese without the MetS and the non-obese, suggesting that it is obesity-related metabolic changes rather than obesity per se linked to increased hs-TnT in children.
Authors: Chiadi E Ndumele; Josef Coresh; Mariana Lazo; Ron C Hoogeveen; Roger S Blumenthal; Aaron R Folsom; Elizabeth Selvin; Christie M Ballantyne; Vijay Nambi Journal: JACC Heart Fail Date: 2014-10-22 Impact factor: 12.035
Authors: Yashashwi Pokharel; Wensheng Sun; Dennis T Villareal; Elizabeth Selvin; Salim S Virani; Chiadi E Ndumele; Ron C Hoogeveen; Josef Coresh; Eric Boerwinkle; Kenneth R Butler; Scott D Solomon; James S Pankow; Biykem Bozkurt; Christie M Ballantyne; Vijay Nambi Journal: Eur J Prev Cardiol Date: 2016-12-12 Impact factor: 7.804
Authors: Renata J M Engler; Michael R Nelson; Limone C Collins; Christina Spooner; Brian A Hemann; Barnett T Gibbs; J Edwin Atwood; Robin S Howard; Audrey S Chang; Daniel L Cruser; Daniel G Gates; Marina N Vernalis; Marguerite S Lengkeek; Bruce M McClenathan; Allan S Jaffe; Leslie T Cooper; Steve Black; Christopher Carlson; Christopher Wilson; Robert L Davis Journal: PLoS One Date: 2015-03-20 Impact factor: 3.240
Authors: Tessa J Parsons; Claudio Sartini; Paul Welsh; Naveed Sattar; Sarah Ash; Lucy T Lennon; S Goya Wannamethee; I-Min Lee; Peter H Whincup; Barbara J Jefferis Journal: Int J Cardiol Date: 2018-01-28 Impact factor: 4.164