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Literature DB >> 23114647

A bilateral primary yolk sac tumor of the lung associated with chromosome 3 polysomy: understanding the Oct 3/4 and Sox 2 interaction.

Shitij Arora, Harish Patel, Pervez Mir, Sneha Mishra, Amita Kalra, Harinder Sawhney, Frantz Duffoo, Mike Macera, Afaf Abdu, William Thelmo.

Abstract

Extragonadal germ cell tumors (EGCTs) in the lung are extremely rare and their pathogenesis is poorly understood. We report a case in a 48-year-old female which was very aggressive and stained positive for primoridial germ cell markers. Interestingly, there was chromosome 3 polysomy noted. To our knowledge this is the first chromosomal aberration noted in a primary germ cell tumor of the lung.

Entities: Disease Gene

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Year: 2012 PMID： 23114647 PMCID： PMC3566046 DOI： 10.4161/cbt.22624

Source DB: PubMed Journal: Cancer Biol Ther ISSN： 1538-4047 Impact factor: 4.742

8 in total

1. Identification of bronchioalveolar stem cells in normal lung and lung cancer.

Authors: Carla F Bender Kim; Erica L Jackson; Amber E Woolfenden; Sharon Lawrence; Imran Babar; Sinae Vogel; Denise Crowley; Roderick T Bronson; Tyler Jacks
Journal: Cell Date: 2005-06-17 Impact factor: 41.582

2. Interaction between Oct3/4 and Cdx2 determines trophectoderm differentiation.

Authors: Hitoshi Niwa; Yayoi Toyooka; Daisuke Shimosato; Dan Strumpf; Kadue Takahashi; Rika Yagi; Janet Rossant
Journal: Cell Date: 2005-12-02 Impact factor: 41.582

3. Extragonadal malignant germ cell tumor of the lung.

Authors: J Pont; N Pridun; N Vesely; H R Kienzer; E Pont; F J Spital
Journal: J Thorac Cardiovasc Surg Date: 1994-01 Impact factor: 5.209

4. A primary pure yolk sac tumor of the lung exhibiting CDX-2 immunoreactivity and increased serum levels of alkaline phosphatase intestinal isoenzyme.

Authors: Giuseppe Pelosi; Francesco Petrella; Maria Teresa Sandri; Lorenzo Spaggiari; Domenico Galetta; Giuseppe Viale
Journal: Int J Surg Pathol Date: 2006-07 Impact factor: 1.271

1 in total

1. A case report of a metastatic yolk sac carcinoma in the pulmonary artery of a young female Sprague-Dawley rat.

Authors: Yohei Sakamoto; Takaharu Nagaoka; Kei Tamura; Hideshi Kaneko
Journal: J Toxicol Pathol Date: 2016-08-04 Impact factor: 1.628

1 in total

A bilateral primary yolk sac tumor of the lung associated with chromosome 3 polysomy: understanding the Oct 3/4 and Sox 2 interaction.

1. Identification of bronchioalveolar stem cells in normal lung and lung cancer.

2. Interaction between Oct3/4 and Cdx2 determines trophectoderm differentiation.

3. Extragonadal malignant germ cell tumor of the lung.

4. A primary pure yolk sac tumor of the lung exhibiting CDX-2 immunoreactivity and increased serum levels of alkaline phosphatase intestinal isoenzyme.

5. Oct-3/4 expression reflects tumor progression and regulates motility of bladder cancer cells.

6. Downregulation of transcription factor SOX2 in cancer stem cells suppresses growth and metastasis of lung cancer.

7. Clinicopathological significance of non-small cell lung cancer with high prevalence of Oct-4 tumor cells.

8. Cytokeratin 7 and 20 staining for the diagnosis of lung and colorectal adenocarcinoma.

1. A case report of a metastatic yolk sac carcinoma in the pulmonary artery of a young female Sprague-Dawley rat.