Luisa A DiPietro1. 1. Center for Wound Healing and Tissue Regeneration, University of Illinois at Chicago, Chicago, Illinois 60612, USA. Ldipiet@uic.eudu
Abstract
PURPOSE OF REVIEW: One well described feature of wound healing is the ingrowth of new capillaries or angiogenesis. At its peak, the capillary content in healing wounds may reach three or more times that of normal uninjured tissue. This new vasculature is required to restore oxygenation and allow the growth of new tissue to fill the wound space. This review examines the assumption that a capillary content in excess of normal density is essential for adequate healing. RECENT FINDINGS: The regulation of wound angiogenesis has been demonstrated to involve both proangiogenic and antiangiogenic stimuli, with the level of capillary growth reliant upon both sets of factors. Several studies now show that normal skin wounds heal adequately even when the angiogenic response is artificially reduced. In normal skin, a reduction of capillary growth to a level consistent with normal tissue does not affect wound closure and may even lead to highly favorable long term healing outcomes. SUMMARY: The angiogenic response in normal wounds may exceed what is needed for optimal repair.
PURPOSE OF REVIEW: One well described feature of wound healing is the ingrowth of new capillaries or angiogenesis. At its peak, the capillary content in healing wounds may reach three or more times that of normal uninjured tissue. This new vasculature is required to restore oxygenation and allow the growth of new tissue to fill the wound space. This review examines the assumption that a capillary content in excess of normal density is essential for adequate healing. RECENT FINDINGS: The regulation of wound angiogenesis has been demonstrated to involve both proangiogenic and antiangiogenic stimuli, with the level of capillary growth reliant upon both sets of factors. Several studies now show that normal skin wounds heal adequately even when the angiogenic response is artificially reduced. In normal skin, a reduction of capillary growth to a level consistent with normal tissue does not affect wound closure and may even lead to highly favorable long term healing outcomes. SUMMARY: The angiogenic response in normal wounds may exceed what is needed for optimal repair.
Authors: Alexander Golberg; Martin Villiger; Saiqa Khan; Kyle P Quinn; William C Y Lo; Brett E Bouma; Martin C Mihm; William G Austen; Martin L Yarmush Journal: J Invest Dermatol Date: 2016-07-05 Impact factor: 8.551
Authors: Elizabeth R Michalczyk; Lin Chen; Mariana B Maia; Luisa A DiPietro Journal: Adv Wound Care (New Rochelle) Date: 2019-12-06 Impact factor: 4.730
Authors: Alexander Golberg; Martin Villiger; G Felix Broelsch; Kyle P Quinn; Hassan Albadawi; Saiqa Khan; Michael T Watkins; Irene Georgakoudi; William G Austen; Marianna Bei; Brett E Bouma; Martin C Mihm; Martin L Yarmush Journal: J Tissue Eng Regen Med Date: 2017-05-23 Impact factor: 3.963
Authors: Clement D Marshall; Michael S Hu; Tripp Leavitt; Leandra A Barnes; H Peter Lorenz; Michael T Longaker Journal: Adv Wound Care (New Rochelle) Date: 2018-02-01 Impact factor: 4.730