Literature DB >> 23113268

Effects of peripheral μ, δ, and Κ-opioid receptor agonists on the levels of anxiety and motor activity of rats.

E V Alexeeva1, G A Nazarova, S K Sudakov.   

Abstract

The effects of intragastric administration of μ-, δ, and Κ-opioid receptor agonists DAMGO, DADLE, and ICI 204,448, respectively, on the anxiety and motor activity of rats in an elevated plus-maze were studied. Peripheral administration of ICI 204,448 produced an anxiolytic effect, but had no effect on motor activity of rats. DAMGO and DADLE reduced motor activity; DADLE also increased anxiety. The data on the opposite effects of ICI 204,448 and DADLE on anxiety confirmed our previous hypothesis on the interactions between the central and peripheral components of the endogenous opioid system.

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Year:  2012        PMID： 23113268     DOI： 10.1007/s10517-012-1809-2

Source DB:  PubMed          Journal:  Bull Exp Biol Med        ISSN： 0007-4888            Impact factor:   0.804


  6 in total

1.  Adolescent forced swim stress increases social anxiety-like behaviors and alters kappa opioid receptor function in the basolateral amygdala of male rats.

Authors:  E I Varlinskaya; J M Johnson; K R Przybysz; T Deak; M R Diaz
Journal:  Prog Neuropsychopharmacol Biol Psychiatry       Date:  2019-11-07       Impact factor: 5.067

Review 2.  Age as a factor in stress and alcohol interactions: A critical role for the kappa opioid system.

Authors:  Marvin Rafael Diaz; Kathryn Renee Przybysz; Siara K Rouzer
Journal:  Alcohol       Date:  2017-10-12       Impact factor: 2.405

3.  Age-dependent regulation of GABA transmission by kappa opioid receptors in the basolateral amygdala of Sprague-Dawley rats.

Authors:  K R Przybysz; D F Werner; M R Diaz
Journal:  Neuropharmacology       Date:  2017-02-03       Impact factor: 5.250

4.  Oxycodone decreases anxiety-like behavior in the elevated plus-maze test in male and female rats.

Authors:  Adriaan W Bruijnzeel; Azin Behnood-Rod; Wendi Malphurs; Ranjithkumar Chellian; Robert M Caudle; Marcelo Febo; Barry Setlow; John K Neubert
Journal:  Behav Pharmacol       Date:  2022-08-03       Impact factor: 2.277

5.  Involvement of Peripheral Opioid Receptors in the Realization of Food Motivation Into Eating Behavior.

Authors:  Sergey Sudakov; Natalia Bogdanova
Journal:  Front Behav Neurosci       Date:  2021-01-12       Impact factor: 3.558

6.  Stress alters social behavior and sensitivity to pharmacological activation of kappa opioid receptors in an age-specific manner in Sprague Dawley rats.

Authors:  Elena I Varlinskaya; Linda Patia Spear; Marvin R Diaz
Journal:  Neurobiol Stress       Date:  2018-09-11
  6 in total

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