Antistress effect of Semax in the course of recovery of spleen lymphoid structures after the stress in rats with different behavioral activity.

We studied the effect of antistress peptide Semax, an ACTH4-10 analogue, on the cellular composition of spleen lymphoid structures in Wistar rats with different stress tolerance in the course of post-stress recovery (days 1, 3, 14, and 30). Preliminary administration of Semax alleviates stress-induced proliferation of macrophages and destructive processes in functionally active zones of the rat spleen on days 1, 3, and 14 after the stress exposure, which attests to its capacity to reduce the adverse effects of 1-h stress load on proliferation of macrophages and destructive processes in functionally active zones of this organ.