Literature DB >> 2311263

Quantitative assay of free and total carnitine using tandem mass spectrometry.

N Kodo1, D S Millington, D L Norwood, C R Roe.   

Abstract

A new, specific method for isotope dilution assay of total and free carnitine in urine has been developed. The method utilizes fast atom bombardment ionization with tandem mass spectrometry and requires minimal sample preparation. It compared well with radioenzymatic assay in terms of specificity, precision and accuracy, but was much more convenient in terms of analysis time and sample throughput. The new method is also applicable to the determination of free and short-chain total carnitine in plasma.

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Year:  1990        PMID: 2311263     DOI: 10.1016/0009-8981(90)90324-l

Source DB:  PubMed          Journal:  Clin Chim Acta        ISSN: 0009-8981            Impact factor:   3.786


  5 in total

1.  Metabolic Profiling of Human Blood by High Resolution Ion Mobility Mass Spectrometry (IM-MS).

Authors:  Prabha Dwivedi; Albert J Schultz; Herbert H Hill
Journal:  Int J Mass Spectrom       Date:  2010-12       Impact factor: 1.986

2.  Acylcarnitine profile in tissues and body fluids of biotin-deficient rats with and without L-carnitine supplementation.

Authors:  Y Shigematsu; I L Bykov; Y Y Liu; A Nakai; Y Kikawa; M Sudo; M Fujioka
Journal:  J Inherit Metab Dis       Date:  1994       Impact factor: 4.982

3.  Respiratory complex II defect in siblings associated with a symptomatic secondary block in fatty acid oxidation.

Authors:  J J Gargus; K Boyle; M Bocian; D S Roe; C Vianey-Saban; C R Roe
Journal:  J Inherit Metab Dis       Date:  2003       Impact factor: 4.982

Review 4.  Pharmacokinetics of L-carnitine.

Authors:  Allan M Evans; Gianfranco Fornasini
Journal:  Clin Pharmacokinet       Date:  2003       Impact factor: 6.447

5.  L-Carnitine-supplementation in advanced pancreatic cancer (CARPAN)--a randomized multicentre trial.

Authors:  Matthias Kraft; Kathleen Kraft; Simone Gärtner; Julia Mayerle; Peter Simon; Eckhard Weber; Kerstin Schütte; Jens Stieler; Heide Koula-Jenik; Peter Holzhauer; Uwe Gröber; Georg Engel; Cornelia Müller; You-Shan Feng; Ali Aghdassi; Claudia Nitsche; Peter Malfertheiner; Maciej Patrzyk; Thomas Kohlmann; Markus M Lerch
Journal:  Nutr J       Date:  2012-07-23       Impact factor: 3.271

  5 in total

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