T Ribera1, L Monreal, M A Delgado, J Ríos, M Prades. 1. Servei de Cirurgia Equina, Departament de Medicina i Cirurgia Animals, Universitat Autònoma de Barcelona, Spain. Thais.Ribera@uab.cat
Abstract
OBJECTIVE: To assess the synovial fibrinolytic pathway activation in adult horses with developmental and degenerative arthropathies such as osteochondritis dissecans (OCD) and osteoarthritis (OA) by measuring synovial D-dimer concentrations. METHODS: Prospective observational clinical study of horses admitted for OCD or OA. Synovial fluid was collected during lameness examination or prior to the surgical procedure, and D-dimer concentration and routine synovial fluid analysis were performed. RESULTS: Fifty-eight horses (14 with OCD, 10 with OA and 34 controls) were included in this study. Synovial D-dimer concentrations of horses with OCD and OA were both higher when compared with controls, but were only significantly different in horses with OCD (p = 0.005). However, no statistical differences were observed when comparing synovial D-dimer concentrations from the OCD horses with the OA-affected horses (p = 0.444). CLINICAL SIGNIFICANCE: Activation of coagulation and fibrinolysis play a role in the pathophysiology of equine OCD and OA.
OBJECTIVE: To assess the synovial fibrinolytic pathway activation in adult horses with developmental and degenerative arthropathies such as osteochondritis dissecans (OCD) and osteoarthritis (OA) by measuring synovial D-dimer concentrations. METHODS: Prospective observational clinical study of horses admitted for OCD or OA. Synovial fluid was collected during lameness examination or prior to the surgical procedure, and D-dimer concentration and routine synovial fluid analysis were performed. RESULTS: Fifty-eight horses (14 with OCD, 10 with OA and 34 controls) were included in this study. Synovial D-dimer concentrations of horses with OCD and OA were both higher when compared with controls, but were only significantly different in horses with OCD (p = 0.005). However, no statistical differences were observed when comparing synovial D-dimer concentrations from the OCDhorses with the OA-affected horses (p = 0.444). CLINICAL SIGNIFICANCE: Activation of coagulation and fibrinolysis play a role in the pathophysiology of equineOCD and OA.
Authors: Stine Mandrup Andreassen; Lise C Berg; Søren Saxmose Nielsen; Annemarie T Kristensen; Stine Jacobsen Journal: BMC Vet Res Date: 2015-06-27 Impact factor: 2.741
Authors: Stine Mandrup Andreassen; Anne Mette Lindberg Vinther; Søren Saxmose Nielsen; Pia Haubro Andersen; Aziz Tnibar; Annemarie T Kristensen; Stine Jacobsen Journal: BMC Vet Res Date: 2017-06-19 Impact factor: 2.741