BACKGROUND: Abnormalities in hippocampal-parahippocampal (H-PH) function are prominent features of schizophrenia and have been associated with deficits in episodic memory. However, it remains unclear whether these abnormalities represent a phenotype related to genetic risk for schizophrenia or whether they are related to disease state. METHOD: We investigated H-PH-mediated behavior and physiology, using blood oxygenation level-dependent functional magnetic resonance imaging (BOLD fMRI), during episodic memory in a sample of patients with schizophrenia, clinically unaffected siblings and healthy subjects. RESULTS: Patients with schizophrenia and unaffected siblings displayed abnormalities in episodic memory performance. During an fMRI memory encoding task, both patients and siblings demonstrated a similar pattern of reduced H-PH engagement compared with healthy subjects. CONCLUSIONS: Our findings suggest that the pathophysiological mechanism underlying the inability of patients with schizophrenia to properly engage the H-PH during episodic memory is related to genetic risk for the disorder. Therefore, H-PH dysfunction can be assumed as a schizophrenia susceptibility-related phenotype.
BACKGROUND: Abnormalities in hippocampal-parahippocampal (H-PH) function are prominent features of schizophrenia and have been associated with deficits in episodic memory. However, it remains unclear whether these abnormalities represent a phenotype related to genetic risk for schizophrenia or whether they are related to disease state. METHOD: We investigated H-PH-mediated behavior and physiology, using blood oxygenation level-dependent functional magnetic resonance imaging (BOLD fMRI), during episodic memory in a sample of patients with schizophrenia, clinically unaffected siblings and healthy subjects. RESULTS:Patients with schizophrenia and unaffected siblings displayed abnormalities in episodic memory performance. During an fMRI memory encoding task, both patients and siblings demonstrated a similar pattern of reduced H-PH engagement compared with healthy subjects. CONCLUSIONS: Our findings suggest that the pathophysiological mechanism underlying the inability of patients with schizophrenia to properly engage the H-PH during episodic memory is related to genetic risk for the disorder. Therefore, H-PH dysfunction can be assumed as a schizophrenia susceptibility-related phenotype.
Authors: Hengyi Cao; Sarah C McEwen; Yoonho Chung; Oliver Y Chén; Carrie E Bearden; Jean Addington; Bradley Goodyear; Kristin S Cadenhead; Heline Mirzakhanian; Barbara A Cornblatt; Ricardo E Carrión; Daniel H Mathalon; Thomas H McGlashan; Diana O Perkins; Aysenil Belger; Larry J Seidman; Heidi Thermenos; Ming T Tsuang; Theo G M van Erp; Elaine F Walker; Stephan Hamann; Alan Anticevic; Scott W Woods; Tyrone D Cannon Journal: Schizophr Bull Date: 2019-06-18 Impact factor: 9.306
Authors: Qiang Chen; Gianluca Ursini; Adrienne L Romer; Annchen R Knodt; Karleigh Mezeivtch; Ena Xiao; Giulio Pergola; Giuseppe Blasi; Richard E Straub; Joseph H Callicott; Karen F Berman; Ahmad R Hariri; Alessandro Bertolino; Venkata S Mattay; Daniel R Weinberger Journal: Brain Date: 2018-04-01 Impact factor: 13.501
Authors: Viola Oertel; Dominik Kraft; Gilberto Alves; Christian Knöchel; Denisa Ghinea; Helena Storchak; Silke Matura; David Prvulovic; Robert A Bittner; David E J Linden; Andreas Reif; Michael Stäblein Journal: Front Psychiatry Date: 2019-02-19 Impact factor: 4.157
Authors: Thomas M Lancaster; Stavros L Dimitriadis; Katherine E Tansey; Gavin Perry; Niklas Ihssen; Derek K Jones; Krish D Singh; Peter Holmans; Andrew Pocklington; George Davey Smith; Stan Zammit; Jeremy Hall; Michael C O'Donovan; Michael J Owen; David E Linden Journal: Schizophr Bull Date: 2019-03-07 Impact factor: 9.306