| Literature DB >> 23110744 |
E Huhtamo1, G Comach, G Sierra, D E Camacho, T Sironen, O Vapalahti, N Y Uzcátegui.
Abstract
Dengue is a mosquito-borne disease caused by four closely related dengue virus (genus Flavivirus)serotypes (DENV-1–4). The clinical outcomes vary from mild febrile illness to life-threatening haemorrhagic manifestations. DENVs are endemic in the tropics and subtropics globally and currently no specific treatment or vaccines are available. In Venezuela, the American-Asian genotype of DENV-2 is the most prevalent and has been associated with severe disease outcomes.We aimed to follow-up the molecular epidemiology of DENV-2 in Venezuela to investigate if the evolution of the virus has remained the same throughout time or if the same dynamics documented in Brazil (hyperendemic co-circulation) also occurred. The results show that whereas the epidemiology of DENV in several endemic areas is characterized by serotype replacements through time, in Venezuela the American-Asian genotype DENV-2 has evolved into several genetic lineages and has remained in hyperendemic co-circulation with the other serotypes.Entities:
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Year: 2012 PMID： 23110744 PMCID： PMC9156957 DOI： 10.1017/S0950268812002324
Source DB: PubMed Journal: Epidemiol Infect ISSN： 0950-2688 Impact factor: 4.434