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Literature DB >> 23109778

Orthostatic hypotension as a manifestation of vitamin B12 deficiency.

Leila Ganjehei¹, Ali Massumi, Mehdi Razavi, James M Wilson.

Abstract

A 90-year-old woman with orthostatic hypotension and near-syncope was found to have a low-normal level of vitamin B(12) and no other medical findings that could explain her orthostasis. Her symptoms responded to vitamin B(12) replacement therapy. This case shows that vitamin B(12) deficiency can induce orthostatic hypotension and syncope that are correctable by vitamin B(12) replacement.

Entities: Chemical Disease Species

Keywords: Hypotension, orthostatic/etiology/therapy; vitamin B 12 deficiency; vitamin B 12 replacement; vitamin B 12/therapeutic use

Mesh：

Substances：

Year: 2012 PMID： 23109778 PMCID： PMC3461697

Source DB: PubMed Journal: Tex Heart Inst J ISSN： 0730-2347

13 in total

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Journal: JAMA Date: 1962-10-13 Impact factor: 56.272

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Authors: Markus Beitzke; Peter Pfister; Jürgen Fortin; Falko Skrabal
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Authors: David S Goldstein; Yehonatan Sharabi
Journal: Circulation Date: 2009-01-06 Impact factor: 29.690

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Authors: Lenee A Lane; Carlos Rojas-Fernandez
Journal: Ann Pharmacother Date: 2002 Jul-Aug Impact factor: 3.154

9. Effects of vitamin B12, folate, and vitamin B6 supplements in elderly people with normal serum vitamin concentrations.

Authors: H J Naurath; E Joosten; R Riezler; S P Stabler; R H Allen; J Lindenbaum
Journal: Lancet Date: 1995-07-08 Impact factor: 79.321

Orthostatic hypotension as a manifestation of vitamin B12 deficiency.

1. Orthostatic hypotension associated with pernicious anemia. Report of a case with complete recovery following vitamin B12 therapy.

2. Autonomic dysfunction and hemodynamics in vitamin B12 deficiency.

Review 3. Pathophysiological basis of orthostatic hypotension in autonomic failure.

4. Diagnosis of cobalamin deficiency: II. Relative sensitivities of serum cobalamin, methylmalonic acid, and total homocysteine concentrations.

Review 5. Autonomic dysfunction in peripheral nerve disease.

6. Pernicious anemia seen initially as orthostatic hypotension.

Review 7. Neurogenic orthostatic hypotension: a pathophysiological approach.

Review 8. Treatment of vitamin b(12)-deficiency anemia: oral versus parenteral therapy.

9. Effects of vitamin B12, folate, and vitamin B6 supplements in elderly people with normal serum vitamin concentrations.

10. High prevalence of cobalamin deficiency in elderly outpatients.

Review 1. Management of neurogenic orthostatic hypotension in patients with autonomic failure.

2. Orthostatic Hypotension and Cardiovascular Death in Older Patients.

3. Neurological symptoms of vitamin B12 deficiency: analysis of pediatric patients.

4. A reversible cause of skin hyperpigmentation and postural hypotension.