Literature DB >> 23109349

Discovery of depsides and depsidones from lichen as potent inhibitors of microsomal prostaglandin E2 synthase-1 using pharmacophore models.

Julia Bauer1, Birgit Waltenberger, Stefan M Noha, Daniela Schuster, Judith M Rollinger, Joel Boustie, Marylene Chollet, Hermann Stuppner, Oliver Werz.   

Abstract

Nature in silico: Virtual screening using validated pharmacophore models identified lichen depsides and depsidones as potential inhibitors of mPGES-1, an emerging target for NSAIDs. Evaluation of the virtual hits in a cell-free assay revealed physodic acid and perlatolic acid as potent inhibitors of mPGES-1 (IC(50) = 0.4 and 0.43 μM, respectively), indicating that these natural products have potential as novel anti-inflammatory agents.
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Year:  2012        PMID： 23109349      PMCID： PMC3524419          DOI： 10.1002/cmdc.201200345

Source DB:  PubMed          Journal:  ChemMedChem        ISSN： 1860-7179            Impact factor:   3.466


  40 in total

1.  Effects of tenuiorin and methyl orsellinate from the lichen Peltigera leucophlebia on 5-/15-lipoxygenases and proliferation of malignant cell lines in vitro.

Authors:  K Ingólfsdóttir; G F Gudmundsdóttir; H M Ogmundsdóttir; K Paulus; S Haraldsdóttir; H Kristinsson; R Bauer
Journal:  Phytomedicine       Date:  2002-10       Impact factor: 5.340

Review 2.  Prostaglandins and leukotrienes: advances in eicosanoid biology.

Authors:  C D Funk
Journal:  Science       Date:  2001-11-30       Impact factor: 47.728

3.  Green tea epigallocatechin-3-gallate inhibits microsomal prostaglandin E(2) synthase-1.

Authors:  Andreas Koeberle; Julia Bauer; Moritz Verhoff; Marika Hoffmann; Hinnak Northoff; Oliver Werz
Journal:  Biochem Biophys Res Commun       Date:  2009-08-06       Impact factor: 3.575

Review 4.  Pharmaceutically relevant metabolites from lichens.

Authors:  K Müller
Journal:  Appl Microbiol Biotechnol       Date:  2001-07       Impact factor: 4.813

5.  Inhibition of microsomal prostaglandin E2 synthase-1 as a molecular basis for the anti-inflammatory actions of boswellic acids from frankincense.

Authors:  U Siemoneit; A Koeberle; A Rossi; F Dehm; M Verhoff; S Reckel; T J Maier; J Jauch; H Northoff; F Bernhard; V Doetsch; L Sautebin; O Werz
Journal:  Br J Pharmacol       Date:  2011-01       Impact factor: 8.739

Review 6.  Microsomal prostaglandin E synthase-1 and 5-lipoxygenase: potential drug targets in cancer.

Authors:  O Rådmark; B Samuelsson
Journal:  J Intern Med       Date:  2010-04-28       Impact factor: 8.989

Review 7.  Nonsteroidal anti-inflammatory drugs: a critical review on current concepts applied to reduce gastrointestinal toxicity.

Authors:  Mona Abdel-Tawab; Heiko Zettl; Manfred Schubert-Zsilavecz
Journal:  Curr Med Chem       Date:  2009       Impact factor: 4.530

8.  Structural basis for induced formation of the inflammatory mediator prostaglandin E2.

Authors:  Caroline Jegerschöld; Sven-Christian Pawelzik; Pasi Purhonen; Priyaranjan Bhakat; Karina Roxana Gheorghe; Nobuhiko Gyobu; Kaoru Mitsuoka; Ralf Morgenstern; Per-Johan Jakobsson; Hans Hebert
Journal:  Proc Natl Acad Sci U S A       Date:  2008-08-05       Impact factor: 11.205

9.  Identification of 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 as functional targets of the anti-inflammatory and anti-carcinogenic garcinol.

Authors:  Andreas Koeberle; Hinnak Northoff; Oliver Werz
Journal:  Biochem Pharmacol       Date:  2009-02-21       Impact factor: 5.858

10.  Licofelone suppresses prostaglandin E2 formation by interference with the inducible microsomal prostaglandin E2 synthase-1.

Authors:  Andreas Koeberle; Ulf Siemoneit; Ulrike Bühring; Hinnak Northoff; Stefan Laufer; Wolfgang Albrecht; Oliver Werz
Journal:  J Pharmacol Exp Ther       Date:  2008-06-11       Impact factor: 4.030
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  9 in total

Review 1.  Counting on natural products for drug design.

Authors:  Tiago Rodrigues; Daniel Reker; Petra Schneider; Gisbert Schneider
Journal:  Nat Chem       Date:  2016-04-25       Impact factor: 24.427

2.  Computational models for the classification of mPGES-1 inhibitors with fingerprint descriptors.

Authors:  Zhonghua Xia; Aixia Yan
Journal:  Mol Divers       Date:  2017-05-08       Impact factor: 2.943

3.  Diversity and antimicrobial activity of culturable fungi from fishscale bamboo (Phyllostachys heteroclada) in China.

Authors:  Ying-Ke Zhou; Xiao-Ye Shen; Cheng-Lin Hou
Journal:  World J Microbiol Biotechnol       Date:  2017-05-02       Impact factor: 3.312

4.  Discovery of novel, non-acidic mPGES-1 inhibitors by virtual screening with a multistep protocol.

Authors:  Stefan M Noha; Katrin Fischer; Andreas Koeberle; Ulrike Garscha; Oliver Werz; Daniela Schuster
Journal:  Bioorg Med Chem       Date:  2015-06-01       Impact factor: 3.641

5.  Potential Antiosteoporotic Natural Product Lead Compounds That Inhibit 17β-Hydroxysteroid Dehydrogenase Type 2.

Authors:  Anna Vuorinen; Roger T Engeli; Susanne Leugger; Fabio Bachmann; Muhammad Akram; Atanas G Atanasov; Birgit Waltenberger; Veronika Temml; Hermann Stuppner; Liselotte Krenn; Sylvin B Ateba; Dieudonné Njamen; Rohan A Davis; Alex Odermatt; Daniela Schuster
Journal:  J Nat Prod       Date:  2017-03-20       Impact factor: 4.050

6.  Comprehensive Lichenometabolomic Exploration of Ramalina conduplicans Vain Using UPLC-Q-ToF-MS/MS: An Identification of Free Radical Scavenging and Anti-Hyperglycemic Constituents.

Authors:  Tatapudi Kiran Kumar; Bandi Siva; Ajay Anand; Komati Anusha; Satish Mohabe; Araveeti Madhusudana Reddy; Françoise Le Devehat; Ashok Kumar Tiwari; Joël Boustie; Katragadda Suresh Babu
Journal:  Molecules       Date:  2022-10-09       Impact factor: 4.927

7.  Imbricaric acid and perlatolic acid: multi-targeting anti-inflammatory depsides from Cetrelia monachorum.

Authors:  Sarah K Oettl; Jana Gerstmeier; Shafaat Y Khan; Katja Wiechmann; Julia Bauer; Atanas G Atanasov; Clemens Malainer; Ezzat M Awad; Pavel Uhrin; Elke H Heiss; Birgit Waltenberger; Daniel Remias; Johannes M Breuss; Joel Boustie; Verena M Dirsch; Hermann Stuppner; Oliver Werz; Judith M Rollinger
Journal:  PLoS One       Date:  2013-10-09       Impact factor: 3.240

Review 8.  Drugs from nature targeting inflammation (DNTI): a successful Austrian interdisciplinary network project.

Authors:  Birgit Waltenberger; Atanas G Atanasov; Elke H Heiss; David Bernhard; Judith M Rollinger; Johannes M Breuss; Daniela Schuster; Rudolf Bauer; Brigitte Kopp; Chlodwig Franz; Valery Bochkov; Marko D Mihovilovic; Verena M Dirsch; Hermann Stuppner
Journal:  Monatsh Chem       Date:  2016-02-25       Impact factor: 1.451

9.  Lichen-Derived Compounds and Extracts as Biologically Active Substances with Anticancer and Neuroprotective Properties.

Authors:  Elżbieta Studzińska-Sroka; Aleksandra Majchrzak-Celińska; Przemysław Zalewski; Dominik Szwajgier; Ewa Baranowska-Wójcik; Barbara Kaproń; Tomasz Plech; Marcin Żarowski; Judyta Cielecka-Piontek
Journal:  Pharmaceuticals (Basel)       Date:  2021-12-10
  9 in total

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