Literature DB >> 23109095

A non-randomized controlled clinical trial on autologous chondrocyte implantation (ACI) in cartilage defects of the medial femoral condyle with or without high tibial osteotomy in patients with varus deformity of less than 5°.

Gerrit Bode1, Hagen Schmal, Jan M Pestka, Peter Ogon, Norbert P Südkamp, Philipp Niemeyer.   

Abstract

PURPOSE: High tibial osteotomy (HTO) is a recommended concomitant surgery when treating cartilage lesions of the medial femoral condyle (MFC). Varus deformities of 5° and more were considered an indication for HTO in patients with cartilage defects. This study compares clinical outcome in patients with ACI and concomitant varus deformity of <5° with or without additional HTO.
METHODS: 43 patients with isolated cartilage defect of the MFC and varus deformity between 1° and 5° (mean age 39.14 ± 8.35 years; mean varus deformity 2.84 ± 1.19°) were included (follow-up 71.88 ± 23.99 months). Group A (n = 19) was treated with ACI and additional HTO; group B (n = 24) received ACI only. Survival rate in terms of absence of the need of reintervention was defined as main outcome parameter. In the subgroup without reintervention, functional outcome (KOOS and WOMAC) was evaluated.
RESULTS: Overall rate of reintervention was 12 (27.9 %). Survival was significantly higher in group A (group A 89.5 %, group B 58.33 %; p = 0.023). Although a trend for better clinical outcome was observed for group A in the subgroup without reintervention, this observation lacked statistical significance (KOOS(symptoms) group A 73.23, group B 59.64; p = 0.274).
CONCLUSION: While there is general consensus for treating varus deformities of >5° in patients with cartilage lesions of the medial femoral condyle, HTO also leads to a reduced rate of reinterventions and longer survival rates in patients with varus deformities of <5°.

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Year:  2012        PMID: 23109095     DOI: 10.1007/s00402-012-1637-x

Source DB:  PubMed          Journal:  Arch Orthop Trauma Surg        ISSN: 0936-8051            Impact factor:   3.067


  35 in total

1.  Prospective 5-year survival rate data following open-wedge valgus high tibial osteotomy.

Authors:  Gerrit Bode; Johanna von Heyden; Jan Pestka; Hagen Schmal; Gian Salzmann; Norbert Südkamp; Philipp Niemeyer
Journal:  Knee Surg Sports Traumatol Arthrosc       Date:  2013-11-19       Impact factor: 4.342

2.  Can young and active patients participate in sports after osteochondral autologous transfer combined with valgus high tibial osteotomy?

Authors:  Philipp Minzlaff; Matthias J Feucht; Tim Saier; Matthias Cotic; Johannes E Plath; Andreas B Imhoff; Stefan Hinterwimmer
Journal:  Knee Surg Sports Traumatol Arthrosc       Date:  2014-12-07       Impact factor: 4.342

Review 3.  [Guidelines for the treatment of unicompartmental cartilage defects of the knee-Cartilage repair, osteotomy, mini-implant or arthroplasty?]

Authors:  Christoph Becher; Andreas Imhoff
Journal:  Orthopade       Date:  2020-12-18       Impact factor: 1.087

4.  Comparison of the efficiency of an extra-articular absorber system and high tibial osteotomy for unloading the medial knee compartment: an in vitro study.

Authors:  Gerrit Bode; Ferdinand Kloos; Matthias J Feucht; Benjamin Fleischer; Norbert Südkamp; Philipp Niemeyer; Christoph Becher
Journal:  Knee Surg Sports Traumatol Arthrosc       Date:  2016-10-19       Impact factor: 4.342

5.  Degree of axis correction in valgus high tibial osteotomy: proposal of an individualised approach.

Authors:  Matthias J Feucht; Philipp Minzlaff; Tim Saier; Matthias Cotic; Norbert P Südkamp; Philipp Niemeyer; Andreas B Imhoff; Stefan Hinterwimmer
Journal:  Int Orthop       Date:  2014-07-10       Impact factor: 3.075

6.  Imaging features of iBalance, a new high tibial osteotomy: what the radiologist needs to know.

Authors:  Erin FitzGerald Alaia; Christopher J Burke; Michael J Alaia; Eric J Strauss; Gina A Ciavarra; Ignacio Rossi; Zehava Sadka Rosenberg
Journal:  Skeletal Radiol       Date:  2016-08-04       Impact factor: 2.199

7.  Osteochondral Allograft Transplantation and Opening Wedge Tibial Osteotomy: Clinical Results of a Combined Single Procedure.

Authors:  Albert C Hsu; Luis E P Tirico; Abraham G Lin; Pamela A Pulido; William D Bugbee
Journal:  Cartilage       Date:  2017-05-22       Impact factor: 4.634

8.  Biological Response Following Inlay Arthroplasty of the Knee: Cartilage Flow Over the Implant.

Authors:  Tahsin Beyzadeoglu; Tuna Pehlivanoglu
Journal:  Cartilage       Date:  2017-12-18       Impact factor: 4.634

9.  Implantation of mesenchymal stem cells in combination with allogenic cartilage improves cartilage regeneration and clinical outcomes in patients with concomitant high tibial osteotomy.

Authors:  Yong Sang Kim; Pill Ku Chung; Dong Suk Suh; Dong Beom Heo; Dae Hyun Tak; Yong Gon Koh
Journal:  Knee Surg Sports Traumatol Arthrosc       Date:  2019-09-23       Impact factor: 4.342

Review 10.  [Cartilage repair of the knee joint].

Authors:  B Rath; J Eschweiler; M Betsch; G Gruber
Journal:  Orthopade       Date:  2017-11       Impact factor: 1.087

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