OBJECTIVE: To investigate five top single nucleotide polymorphisms (SNPs) located in different genes and loci (CHRNA3, BDNF, DBH and LOC100188947) that were highly associated with different dimensions of smoking behaviour, in relation to attention-deficit hyperactivity disorder (ADHD). DESIGN: Cohort study consisting of a clinical sample of children with ADHD. SETTING: Douglas Institute ADHD Clinic, Montreal, Canada. PATIENTS: Families of 454 children with ADHD aged 6-12 years old. INTERVENTIONS: Family-based association tests used to study the transmission of risk alleles within these five genetic markers. MAIN OUTCOME MEASURES: Clinical diagnosis of ADHD, and a number of behavioural and neurocognitive phenotypes relevant to the disorder. RESULTS: One SNP (rs1329650) from a non-coding RNA (LOC100188947) was significantly associated with overall ADHD diagnosis with the C* risk allele being over-transmitted from parents to children with ADHD (p=0.02). It was also over-transmitted to children with higher scores on Conners' Parents (p=0.01) and Conners' Teacher (p=0.002) index scores, and Child Behaviour Checklist withdrawn (p=0.001) and aggressive (p=0.007) behaviours. Children with poorer performances on executive and attention tasks were more likely to inherit the risk allele. CONCLUSIONS: The C* allele of rs1329650 may be increasing the risk for ADHD and smoking behaviour through a common mechanism, possibly externalising behaviours and specific cognitive deficits that manifest as ADHD in childhood and are the gateway to smoking behaviour later in life. This exploratory study illustrates the use of comorbid disorders to investigate ADHD genetics. In spite of its relatively large sample size, replication in future studies is warranted.
OBJECTIVE: To investigate five top single nucleotide polymorphisms (SNPs) located in different genes and loci (CHRNA3, BDNF, DBH and LOC100188947) that were highly associated with different dimensions of smoking behaviour, in relation to attention-deficit hyperactivity disorder (ADHD). DESIGN: Cohort study consisting of a clinical sample of children with ADHD. SETTING: Douglas Institute ADHD Clinic, Montreal, Canada. PATIENTS: Families of 454 children with ADHD aged 6-12 years old. INTERVENTIONS: Family-based association tests used to study the transmission of risk alleles within these five genetic markers. MAIN OUTCOME MEASURES: Clinical diagnosis of ADHD, and a number of behavioural and neurocognitive phenotypes relevant to the disorder. RESULTS: One SNP (rs1329650) from a non-coding RNA (LOC100188947) was significantly associated with overall ADHD diagnosis with the C* risk allele being over-transmitted from parents to children with ADHD (p=0.02). It was also over-transmitted to children with higher scores on Conners' Parents (p=0.01) and Conners' Teacher (p=0.002) index scores, and Child Behaviour Checklist withdrawn (p=0.001) and aggressive (p=0.007) behaviours. Children with poorer performances on executive and attention tasks were more likely to inherit the risk allele. CONCLUSIONS: The C* allele of rs1329650 may be increasing the risk for ADHD and smoking behaviour through a common mechanism, possibly externalising behaviours and specific cognitive deficits that manifest as ADHD in childhood and are the gateway to smoking behaviour later in life. This exploratory study illustrates the use of comorbid disorders to investigate ADHD genetics. In spite of its relatively large sample size, replication in future studies is warranted.
Authors: Thomas R Fanshawe; William Halliwell; Nicola Lindson; Paul Aveyard; Jonathan Livingstone-Banks; Jamie Hartmann-Boyce Journal: Cochrane Database Syst Rev Date: 2017-11-17
Authors: Pedro J Puentes-Rozo; Johan E Acosta-López; Martha L Cervantes-Henríquez; Martha L Martínez-Banfi; Elsy Mejia-Segura; Manuel Sánchez-Rojas; Marco E Anaya-Romero; Antonio Acosta-Hoyos; Guisselle A García-Llinás; Claudio A Mastronardi; David A Pineda; F Xavier Castellanos; Mauricio Arcos-Burgos; Jorge I Vélez Journal: Cells Date: 2019-08-16 Impact factor: 6.600
Authors: A Mesut Erzurumluoglu; Mengzhen Liu; Victoria E Jackson; Martin D Tobin; Scott Vrieze; Dajiang J Liu; Joanna M M Howson; Daniel R Barnes; Gargi Datta; Carl A Melbourne; Robin Young; Chiara Batini; Praveen Surendran; Tao Jiang; Sheikh Daud Adnan; Saima Afaq; Arpana Agrawal; Elisabeth Altmaier; Antonis C Antoniou; Folkert W Asselbergs; Clemens Baumbach; Laura Bierut; Sarah Bertelsen; Michael Boehnke; Michiel L Bots; David M Brazel; John C Chambers; Jenny Chang-Claude; Chu Chen; Janie Corley; Yi-Ling Chou; Sean P David; Rudolf A de Boer; Christiaan A de Leeuw; Joe G Dennis; Anna F Dominiczak; Alison M Dunning; Douglas F Easton; Charles Eaton; Paul Elliott; Evangelos Evangelou; Jessica D Faul; Tatiana Foroud; Alison Goate; Jian Gong; Hans J Grabe; Jeff Haessler; Christopher Haiman; Göran Hallmans; Anke R Hammerschlag; Sarah E Harris; Andrew Hattersley; Andrew Heath; Chris Hsu; William G Iacono; Stavroula Kanoni; Manav Kapoor; Jaakko Kaprio; Sharon L Kardia; Fredrik Karpe; Jukka Kontto; Jaspal S Kooner; Charles Kooperberg; Kari Kuulasmaa; Markku Laakso; Dongbing Lai; Claudia Langenberg; Nhung Le; Guillaume Lettre; Anu Loukola; Jian'an Luan; Pamela A F Madden; Massimo Mangino; Riccardo E Marioni; Eirini Marouli; Jonathan Marten; Nicholas G Martin; Matt McGue; Kyriaki Michailidou; Evelin Mihailov; Alireza Moayyeri; Marie Moitry; Martina Müller-Nurasyid; Aliya Naheed; Matthias Nauck; Matthew J Neville; Sune Fallgaard Nielsen; Kari North; Markus Perola; Paul D P Pharoah; Giorgio Pistis; Tinca J Polderman; Danielle Posthuma; Neil Poulter; Beenish Qaiser; Asif Rasheed; Alex Reiner; Frida Renström; John Rice; Rebecca Rohde; Olov Rolandsson; Nilesh J Samani; Maria Samuel; David Schlessinger; Steven H Scholte; Robert A Scott; Peter Sever; Yaming Shao; Nick Shrine; Jennifer A Smith; John M Starr; Kathleen Stirrups; Danielle Stram; Heather M Stringham; Ioanna Tachmazidou; Jean-Claude Tardif; Deborah J Thompson; Hilary A Tindle; Vinicius Tragante; Stella Trompet; Valerie Turcot; Jessica Tyrrell; Ilonca Vaartjes; Andries R van der Leij; Peter van der Meer; Tibor V Varga; Niek Verweij; Henry Völzke; Nicholas J Wareham; Helen R Warren; David R Weir; Stefan Weiss; Leah Wetherill; Hanieh Yaghootkar; Ersin Yavas; Yu Jiang; Fang Chen; Xiaowei Zhan; Weihua Zhang; Wei Zhao; Wei Zhao; Kaixin Zhou; Philippe Amouyel; Stefan Blankenberg; Mark J Caulfield; Rajiv Chowdhury; Francesco Cucca; Ian J Deary; Panos Deloukas; Emanuele Di Angelantonio; Marco Ferrario; Jean Ferrières; Paul W Franks; Tim M Frayling; Philippe Frossard; Ian P Hall; Caroline Hayward; Jan-Håkan Jansson; J Wouter Jukema; Frank Kee; Satu Männistö; Andres Metspalu; Patricia B Munroe; Børge Grønne Nordestgaard; Colin N A Palmer; Veikko Salomaa; Naveed Sattar; Timothy Spector; David Peter Strachan; Pim van der Harst; Eleftheria Zeggini; Danish Saleheen; Adam S Butterworth; Louise V Wain; Goncalo R Abecasis; John Danesh Journal: Mol Psychiatry Date: 2019-01-07 Impact factor: 13.437