OBJECTIVE: Necrotizing enterocolitis (NEC) is a common and devastating gastrointestinal condition of neonatal infants. The pathophysiology of NEC remains poorly understood. We tried to evaluate the effectiveness of inhaled NO compared to L-arginine usage in necrotizing enterocolitis model in rats. MATERIAL- METHODS: 46 newborn pups from 4 time-mated Sprague-Dawley pregnant rats were divided equally into 4 groups as follows: NEC (subjected to NEC), NEC + L-arginine, NEC + inhaled NO and control. RESULTS: SOD, GSH-Px and NOx levels were significantly higher and MDA levels were significantly lower in NEC + inhaled NO group compared to NEC + L-arginine group. There was significantly lower intestinal injury and apoptosis index scoring in NEC + inhaled NO group compared to NEC + L-arginine group. CONCLUSION: We think that inhaled NO can be used as a novel therapeutic agent like L-arginine in NEC, like using in pulmonary hypertention in newborns but much more studies are needed.
OBJECTIVE:Necrotizing enterocolitis (NEC) is a common and devastating gastrointestinal condition of neonatal infants. The pathophysiology of NEC remains poorly understood. We tried to evaluate the effectiveness of inhaled NO compared to L-arginine usage in necrotizing enterocolitis model in rats. MATERIAL- METHODS: 46 newborn pups from 4 time-mated Sprague-Dawley pregnant rats were divided equally into 4 groups as follows: NEC (subjected to NEC), NEC + L-arginine, NEC + inhaled NO and control. RESULTS: SOD, GSH-Px and NOx levels were significantly higher and MDA levels were significantly lower in NEC + inhaled NO group compared to NEC + L-arginine group. There was significantly lower intestinal injury and apoptosis index scoring in NEC + inhaled NO group compared to NEC + L-arginine group. CONCLUSION: We think that inhaled NO can be used as a novel therapeutic agent like L-arginine in NEC, like using in pulmonary hypertention in newborns but much more studies are needed.
Authors: A Fox-Robichaud; D Payne; S U Hasan; L Ostrovsky; T Fairhead; P Reinhardt; P Kubes Journal: J Clin Invest Date: 1998-06-01 Impact factor: 14.808
Authors: S A Zamora; H J Amin; D D McMillan; P Kubes; G H Fick; J D Bützner; H G Parsons; R B Scott Journal: J Pediatr Date: 1997-08 Impact factor: 4.406
Authors: John D Lang; Xinjun Teng; Phillip Chumley; Jack H Crawford; T Scott Isbell; Balu K Chacko; Yuliang Liu; Nirag Jhala; D Ralph Crowe; Alvin B Smith; Richard C Cross; Luc Frenette; Eric E Kelley; Diana W Wilhite; Cheryl R Hall; Grier P Page; Michael B Fallon; J Steven Bynon; Devin E Eckhoff; Rakesh P Patel Journal: J Clin Invest Date: 2007-09 Impact factor: 14.808