Literature DB >> 23108947

The synthesis of low molecular weight pyrrolo[2,3-c]pyridine-7-one scaffold.

Maxim A Nechayev1, Nikolay Yu Gorobets, Alexander V Borisov, Sergiy M Kovalenko, Andrey A Tolmachev.   

Abstract

A facile method for the synthesis of substituted pyrrolo[2,3-c]pyridine-7-ones is developed that applies an acid-promoted intramolecular cyclization of 2-pyrrolecarboxylic acid amidoacetals as key step. The synthesis is easily scaled up to 1.5 mol quantity with no yield decrease. The alkylation/arylation reaction of the pyrrolo[2,3-c]pyridine-7-ones proceeds regioselectively giving N6-substituted derivatives.

Entities:  

Mesh：

Substances：

Year:  2012        PMID： 23108947     DOI： 10.1007/s11030-012-9410-1

Source DB:  PubMed          Journal:  Mol Divers        ISSN： 1381-1991            Impact factor:   2.943


  7 in total

Review 1.  Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings.

Authors:  C A Lipinski; F Lombardo; B W Dominy; P J Feeney
Journal:  Adv Drug Deliv Rev       Date:  2001-03-01       Impact factor: 15.470

2.  Development of a virtual screening method for identification of "frequent hitters" in compound libraries.

Authors:  Olivier Roche; Petra Schneider; Jochen Zuegge; Wolfgang Guba; Manfred Kansy; Alexander Alanine; Konrad Bleicher; Franck Danel; Eva-Maria Gutknecht; Mark Rogers-Evans; Werner Neidhart; Henri Stalder; Michael Dillon; Eric Sjögren; Nader Fotouhi; Paul Gillespie; Robert Goodnow; William Harris; Phil Jones; Mikio Taniguchi; Shinji Tsujii; Wolfgang von der Saal; Gerd Zimmermann; Gisbert Schneider
Journal:  J Med Chem       Date:  2002-01-03       Impact factor: 7.446

3.  Ugibohlin: a new dibromo-seco-isophakellin from Axinella carteri.

Authors:  G H Goetz; G G Harrigan; J Likos
Journal:  J Nat Prod       Date:  2001-12       Impact factor: 4.050

Review 4.  Molecular diversity in the context of leadlikeness: compound properties that enable effective biochemical screening.

Authors:  Gilbert M Rishton
Journal:  Curr Opin Chem Biol       Date:  2008-03-25       Impact factor: 8.822

5.  New antifeedant bromopyrrole alkaloid from the Caribbean sponge Stylissa caribica.

Authors:  M Assmann; R W van Soest; M Köck
Journal:  J Nat Prod       Date:  2001-10       Impact factor: 4.050

6.  Diversification of a thieno[2,3-d]pyrimidin-4-one scaffold via regioselective alkylation reactions.

Authors:  Sergey G Dzhavakhishvili; Nikolay Yu Gorobets; Svetlana V Shishkina; Oleg V Shishkin; Sergey M Desenko; Ulrich M Groth
Journal:  J Comb Chem       Date:  2009 May-Jun

7.  Generation of 500-member library of 10-alkyl-2-R(1),3-R(2)-4,10-dihydrobenzo[4,5]imidazo[1,2-alpha]pyrimidin-4-ones.

Authors:  Svetlana M Sirko; Nikolay Yu Gorobets; Vladimir I Musatov; Sergey M Desenko
Journal:  Molecules       Date:  2009-12-15       Impact factor: 4.411
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.