Mauro Felippe Felix Mediano1, Rosely Sichieri. 1. Department of Clinical and Experimental Medicine, Institute of Social Medicine, State University of Rio de Janeiro, Rio de Janeiro, Brazil. mffmediano@gmail.com
Abstract
OBJECTIVE: The present study aimed to evaluate whether baseline insulin resistance (IR) modify weight change associated to glycemic index (GI) of the diet. METHOD: This is a secondary analysis of a randomized GI intervention according to baseline HOMA-IR. Middle-aged (25-45 years), non-obese (BMI 23-29.9 kg/m²) women were randomized to low or high GI diets matched on total energy, macronutrient composition, and fiber content. Both groups received dietary counseling based on a small energy restriction (100-300 kcal/day). Women were classified in two groups according to their baseline HOMA-IR: IR (n = 64) and non-IR (n = 121). RESULTS: At baseline, IR and non-IR groups had similar BMI (26.7 vs. 26.3 kg/m²; p = 0.21), but the IR group presented with higher waist circumference (82.7 vs. 80.8 cm; p = 0.02) and showed greater weight loss after 12 months of follow-up (-1.6 vs. -1.1 kg; p = 0.01), mainly among those in a high-GI diet (-2.1 vs. -1.0 kg; p = 0.005) compared to the non-IR group (-1.4 vs. -0.8 kg; p = 0.04). CONCLUSIONS: The high-GI group showed statistically significant higher reduction in body weight, mainly among those women with baseline IR . Low-GI diet did not facilitate weight loss neither in IR women nor in non-IR women.
RCT Entities:
OBJECTIVE: The present study aimed to evaluate whether baseline insulin resistance (IR) modify weight change associated to glycemic index (GI) of the diet. METHOD: This is a secondary analysis of a randomized GI intervention according to baseline HOMA-IR. Middle-aged (25-45 years), non-obese (BMI 23-29.9 kg/m²) women were randomized to low or high GI diets matched on total energy, macronutrient composition, and fiber content. Both groups received dietary counseling based on a small energy restriction (100-300 kcal/day). Women were classified in two groups according to their baseline HOMA-IR: IR (n = 64) and non-IR (n = 121). RESULTS: At baseline, IR and non-IR groups had similar BMI (26.7 vs. 26.3 kg/m²; p = 0.21), but the IR group presented with higher waist circumference (82.7 vs. 80.8 cm; p = 0.02) and showed greater weight loss after 12 months of follow-up (-1.6 vs. -1.1 kg; p = 0.01), mainly among those in a high-GI diet (-2.1 vs. -1.0 kg; p = 0.005) compared to the non-IR group (-1.4 vs. -0.8 kg; p = 0.04). CONCLUSIONS: The high-GI group showed statistically significant higher reduction in body weight, mainly among those women with baseline IR . Low-GI diet did not facilitate weight loss neither in IR women nor in non-IR women.
Authors: Christine Clar; Lena Al-Khudairy; Emma Loveman; Sarah Am Kelly; Louise Hartley; Nadine Flowers; Roberta Germanò; Gary Frost; Karen Rees Journal: Cochrane Database Syst Rev Date: 2017-07-31