BACKGROUND: Original Fried's frailty criteria have not demonstrated their prognostic validity of mortality, disability and mobility loss in European cohorts. OBJECTIVES: To analyze whether frailty implies increased risk of death, incident disability in basic (BADL) or instrumental (IADL) activities of daily living, or mobility impairment. DESIGN: Concurrent cohort study. SETTING: Albacete City, Spain. PARTICIPANTS: 993 participants over age 70 from the FRADEA Study. MEASUREMENTS: Mortality, BADL and mobility using the Barthel Index, and IADL using the Lawton IADL Index, were recorded. BADL disability was defined as loss of the ability to perform bathing, grooming, dressing, toilet use, or feeding, while deterioration of mobility was defined as loss of ability to perform transfers, walk, or use stairs, and IADL disability as losing any of the activities included in the Lawton Index. The risk of presenting adverse events was determined by Cox and Kaplan-Meier proportional hazard analysis and logistic regression adjusted for age, sex, function, and comorbidity. RESULTS: Mean follow-up was 534 days (SD 153), during which 105 participants (10.6%) died. Mean time to death was 363 days (SD 218), while 192 (25.4%) lost at least one BADL, 492 (60%) at least one IADL, and 222 (28.9%) lost mobility. Frail subjects had a greater adjusted risk of death (HR 5.5, CI 95% 1.5-20.2), of losing BADL (HR 2.5, CI 95% 1.3-4.8), of losing mobility (HR 2.7, CI 95% 1.5-5.0), and of losing IADL (HR 1.9, CI 95% 1.1-3.3) than non-frail patients. CONCLUSION: Fried's frailty criteria are associated with death, incident disability, and mobility impairment in a Spanish cohort of older adults.
BACKGROUND: Original Fried's frailty criteria have not demonstrated their prognostic validity of mortality, disability and mobility loss in European cohorts. OBJECTIVES: To analyze whether frailty implies increased risk of death, incident disability in basic (BADL) or instrumental (IADL) activities of daily living, or mobility impairment. DESIGN: Concurrent cohort study. SETTING: Albacete City, Spain. PARTICIPANTS: 993 participants over age 70 from the FRADEA Study. MEASUREMENTS: Mortality, BADL and mobility using the Barthel Index, and IADL using the Lawton IADL Index, were recorded. BADL disability was defined as loss of the ability to perform bathing, grooming, dressing, toilet use, or feeding, while deterioration of mobility was defined as loss of ability to perform transfers, walk, or use stairs, and IADL disability as losing any of the activities included in the Lawton Index. The risk of presenting adverse events was determined by Cox and Kaplan-Meier proportional hazard analysis and logistic regression adjusted for age, sex, function, and comorbidity. RESULTS: Mean follow-up was 534 days (SD 153), during which 105 participants (10.6%) died. Mean time to death was 363 days (SD 218), while 192 (25.4%) lost at least one BADL, 492 (60%) at least one IADL, and 222 (28.9%) lost mobility. Frail subjects had a greater adjusted risk of death (HR 5.5, CI 95% 1.5-20.2), of losing BADL (HR 2.5, CI 95% 1.3-4.8), of losing mobility (HR 2.7, CI 95% 1.5-5.0), and of losing IADL (HR 1.9, CI 95% 1.1-3.3) than non-frail patients. CONCLUSION: Fried's frailty criteria are associated with death, incident disability, and mobility impairment in a Spanish cohort of older adults.
Authors: P Abizanda; L Romero; P M Sánchez-Jurado; M Martínez-Reig; S A Alfonso-Silguero; L Rodríguez-Mañas Journal: J Nutr Health Aging Date: 2014 Impact factor: 4.075
Authors: M Martínez-Reig; L Gómez-Arnedo; S A Alfonso-Silguero; G Juncos-Martínez; L Romero; P Abizanda Journal: J Nutr Health Aging Date: 2014-03 Impact factor: 4.075
Authors: Pedro Abizanda; Luis Romero; Pedro M Sánchez-Jurado; Teresa Flores Ruano; Sergio Salmerón Ríos; Miguel Fernández Sánchez Journal: J Gerontol A Biol Sci Med Sci Date: 2015-10-13 Impact factor: 6.053
Authors: Beatriz Caballero; Adrián Rubio-González; Yaiza Potes; Marta Martínez-Reig; Pedro Manuel Sánchez-Jurado; Luis Romero; Juan José Solano; Pedro Abizanda; Ana Coto-Montes Journal: Age (Dordr) Date: 2014-01-03
Authors: I García-Nogueras; I Aranda-Reneo; L M Peña-Longobardo; J Oliva-Moreno; P Abizanda Journal: J Nutr Health Aging Date: 2017 Impact factor: 4.075
Authors: Francisco J Martín-Sánchez; Michael Christ; Òscar Miró; W Frank Peacock; John J McMurray; Héctor Bueno; Alan S Maisel; Louise Cullen; Martin R Cowie; Salvatore Di Somma; Elke Platz; Josep Masip; Uwe Zeymer; Christiaan Vrints; Susanna Price; Christian Mueller Journal: Int J Cardiol Date: 2016-07-18 Impact factor: 4.164
Authors: Sari Stenholm; Luigi Ferrucci; Jussi Vahtera; Emiel O Hoogendijk; Martijn Huisman; Jaana Pentti; Joni V Lindbohm; Stefania Bandinelli; Jack M Guralnik; Mika Kivimäki Journal: J Gerontol A Biol Sci Med Sci Date: 2019-04-23 Impact factor: 6.053