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Literature DB >> 23107589

Inhibition of the IL-6 signaling pathway: a strategy to combat chronic inflammatory diseases and cancer.

Parvin Ataie-Kachoie¹, Mohammad H Pourgholami, David L Morris.

Abstract

Interleukin (IL)-6 is a pro-inflammatory cytokine that produces multifunctional effects. Deregulated IL-6 production and signaling are associated with chronic inflammatory diseases, auto-immunity and cancer. On this basis, inhibition of IL-6 production, its receptors or the signaling pathways are strategies currently being widely pursued to develop novel therapies for a wide range of diseases. This survey aims to provide an updated account of why IL-6 inhibitors are shaping up to become an important class of drugs potentially useful in the treatment of ailments and in particular in inflammation and cancer. In addition we discuss the role of different agents in modulating IL-6 and also recent clinical studies targeting IL-6 in inflammation-mediated diseases and cancer.

Entities: Disease Gene

Mesh：

Substances：
Interleukin-6

Year: 2012 PMID： 23107589 DOI： 10.1016/j.cytogfr.2012.09.001

Source DB: PubMed Journal: Cytokine Growth Factor Rev ISSN： 1359-6101 Impact factor: 7.638

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Cited

33 in total

1. Interleukin-6 and interleukin-10 as acute kidney injury biomarkers in pediatric cardiac surgery.

Authors: Jason H Greenberg; Richard Whitlock; William R Zhang; Heather R Thiessen-Philbrook; Michael Zappitelli; Prasad Devarajan; John Eikelboom; Peter A Kavsak; P J Devereaux; Colleen Shortt; Amit X Garg; Chirag R Parikh
Journal: Pediatr Nephrol Date: 2015-04-15 Impact factor: 3.714

2. Predictive value of salivary microRNA-320a, vascular endothelial growth factor receptor 2, CRP and IL-6 in Oral lichen planus progression.

Authors: Minoo Shahidi; Soudeh Jafari; Mahmood Barati; Masoumeh Mahdipour; Mohammad Saeed Gholami
Journal: Inflammopharmacology Date: 2017-05-13 Impact factor: 4.473

3. D-pinitol mitigates tumor growth by modulating interleukins and hormones and induces apoptosis in rat breast carcinogenesis through inhibition of NF-κB.

Authors: Thamaraiselvan Rengarajan; Natarajan Nandakumar; Peramaiyan Rajendran; Mohanraj Karthik Ganesh; Maruthaiveeran Periyasamy Balasubramanian; Ikuo Nishigaki
Journal: J Physiol Biochem Date: 2015-04-01 Impact factor: 4.158

4. Tocilizumab promotes corneal allograft survival in rats by modulating Treg-Th17 balance.

Authors: Xiao-Song Wu; Xiao-Li Lu; Jing Wu; Ming Ma; Jian Yu; Zhen-Yu Zhang
Journal: Int J Ophthalmol Date: 2019-12-18 Impact factor: 1.779

Review 5. Cerebral Aneurysm and Interleukin-6: a Key Player in Aneurysm Generation and Rupture or Just One of the Multiple Factors?

Authors: Molly Monsour; Davide Marco Croci; Basil E Grüter; Philipp Taussky; Serge Marbacher; Siviero Agazzi
Journal: Transl Stroke Res Date: 2022-08-31 Impact factor: 6.800

10. Minocycline suppresses interleukine-6, its receptor system and signaling pathways and impairs migration, invasion and adhesion capacity of ovarian cancer cells: in vitro and in vivo studies.

Authors: Parvin Ataie-Kachoie; David L Morris; Mohammad H Pourgholami
Journal: PLoS One Date: 2013-04-08 Impact factor: 3.240

Inhibition of the IL-6 signaling pathway: a strategy to combat chronic inflammatory diseases and cancer.

1. Interleukin-6 and interleukin-10 as acute kidney injury biomarkers in pediatric cardiac surgery.

2. Predictive value of salivary microRNA-320a, vascular endothelial growth factor receptor 2, CRP and IL-6 in Oral lichen planus progression.

3. D-pinitol mitigates tumor growth by modulating interleukins and hormones and induces apoptosis in rat breast carcinogenesis through inhibition of NF-κB.

4. Tocilizumab promotes corneal allograft survival in rats by modulating Treg-Th17 balance.

Review 5. Cerebral Aneurysm and Interleukin-6: a Key Player in Aneurysm Generation and Rupture or Just One of the Multiple Factors?

6. RAID3--An interleukin-6 receptor-binding aptamer with post-selective modification-resistant affinity.

7. Elevated interleukin-6 expression levels are associated with intervertebral disc degeneration.

Review 8. Inhibition of the interleukin-6 signaling pathway: a strategy to induce immune tolerance.

9. Diacerein-mediated inhibition of IL-6/IL-6R signaling induces apoptotic effects on breast cancer.

10. Minocycline suppresses interleukine-6, its receptor system and signaling pathways and impairs migration, invasion and adhesion capacity of ovarian cancer cells: in vitro and in vivo studies.