BACKGROUND: Disorders of thyroid function have been inconsistently described in cystic fibrosis (CF) patients and in CF transmembrane regulator protein knockout animals. The literature lacks reports on iodine status of CF individuals. We hypothesize, that iodine deficiency is common in CF and account for abnormal thyroid function in CF patients. METHODS: We investigated 129 children, adolescents, and adults with CF, who were living in the northern part of Bavaria/Germany. Malnutrition and lung function were analyzed. Urinary iodine excretion, TSH (thyroid-stimulating hormone), and ft4 (free thyroxine) were measured and set in relation to population-based, age-adjusted reference ranges. RESULTS: Subclinical hypothyroidism (normal fT4, elevated TSH) was found in 11.6% of subjects, and iodine deficiency in 83.7%. No correlations were found with age, BMI, status of malnutrition, or lung function. CONCLUSION: Dramatic iodine deficiency was found in our cohort of CF patients. This condition can cause subclinical hypothyroidism; therefore, an individual iodine supplementation program is necessary and should be started immediately. Crown
BACKGROUND: Disorders of thyroid function have been inconsistently described in cystic fibrosis (CF) patients and in CF transmembrane regulator protein knockout animals. The literature lacks reports on iodine status of CF individuals. We hypothesize, that iodine deficiency is common in CF and account for abnormal thyroid function in CFpatients. METHODS: We investigated 129 children, adolescents, and adults with CF, who were living in the northern part of Bavaria/Germany. Malnutrition and lung function were analyzed. Urinary iodine excretion, TSH (thyroid-stimulating hormone), and ft4 (free thyroxine) were measured and set in relation to population-based, age-adjusted reference ranges. RESULTS:Subclinical hypothyroidism (normal fT4, elevated TSH) was found in 11.6% of subjects, and iodine deficiency in 83.7%. No correlations were found with age, BMI, status of malnutrition, or lung function. CONCLUSION: Dramatic iodine deficiency was found in our cohort of CFpatients. This condition can cause subclinical hypothyroidism; therefore, an individual iodine supplementation program is necessary and should be started immediately. Crown
Authors: Kathleen M Aicher; John M Cullen; Gabriela S Seiler; Katharine F Lunn; Kyle G Mathews; Jody L Gookin Journal: PLoS One Date: 2019-02-27 Impact factor: 3.240
Authors: Cibele Zanardi Esteves; Letícia de Aguiar Dias; Estela de Oliveira Lima; Diogo Noin de Oliveira; Carlos Fernando Odir Rodrigues Melo; Jeany Delafiori; Carla Cristina Souza Gomez; José Dirceu Ribeiro; Antônio Fernando Ribeiro; Carlos Emílio Levy; Rodrigo Ramos Catharino Journal: Front Pediatr Date: 2018-01-10 Impact factor: 3.418