Literature DB >> 23107111

Transcription factor-7-like 2 gene variants are strongly associated with type 2 diabetes in Lebanese subjects.

Rita Nemr1, Amira Turki, Akram Echtay, Ghadeer S Al-Zaben, Hoda S Daher, Noha A Irani-Hakime, Sose H Keleshian, Wassim Y Almawi.   

Abstract

We tested the association of TCF7L2 variants with type 2 diabetes (T2DM) in 691 Lebanese people and 919 controls. rs7901695, rs4506565, rs7903146, rs12243326, rs7895340, and rs12255372 minor allele frequencies were higher in T2DM. Haplotype analysis (rs7901695-rs4506565-rs7903146-rs12243326-rs7895340-rs11196205-rs12255372) identified positively- (2122112, 2222222) and negatively- (1111111) T2DM-associated haplotypes. TCF7L2 is a common T2DM candidate gene in Lebanese people.
Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

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Year:  2012        PMID： 23107111     DOI： 10.1016/j.diabres.2012.09.044

Source DB:  PubMed          Journal:  Diabetes Res Clin Pract        ISSN： 0168-8227            Impact factor:   5.602


  8 in total

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Authors:  Habiba Al-Safar; Ahmed Hassoun; Shaikha Almazrouei; Wala Kamal; Bachar Afandi; Naushad Rais
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Authors:  Christina Votsi; Costas Toufexis; Kyriaki Michailidou; Athos Antoniades; Nicos Skordis; Minas Karaolis; Constantinos S Pattichis; Kyproula Christodoulou
Journal:  Genes (Basel)       Date:  2017-01-06       Impact factor: 4.096

4.  Targeted deletion of Tcf7l2 in adipocytes promotes adipocyte hypertrophy and impaired glucose metabolism.

Authors:  Gisela Geoghegan; Judith Simcox; Marcus M Seldin; Timothy J Parnell; Chris Stubben; Steven Just; Lori Begaye; Aldons J Lusis; Claudio J Villanueva
Journal:  Mol Metab       Date:  2019-03-14       Impact factor: 7.422

5.  Identification of CpG-SNPs associated with type 2 diabetes and differential DNA methylation in human pancreatic islets.

Authors:  T A Dayeh; A H Olsson; P Volkov; P Almgren; T Rönn; C Ling
Journal:  Diabetologia       Date:  2013-03-06       Impact factor: 10.122

Review 6.  Association of rs12255372 in the TCF7L2 gene with type 2 diabetes mellitus: a meta-analysis.

Authors:  Jinjin Wang; Jianfeng Zhang; Linlin Li; Yan Wang; Qian Wang; Yujia Zhai; Haifei You; Dongsheng Hu
Journal:  Braz J Med Biol Res       Date:  2013-04-12       Impact factor: 2.590

7.  The TCF7L2 rs7903146 polymorphism, dietary intakes and type 2 diabetes risk in an Algerian population.

Authors:  Hadjira Ouhaibi-Djellouli; Sounnia Mediene-Benchekor; Sarah Aïcha Lardjam-Hetraf; Imane Hamani-Medjaoui; Djabaria Naima Meroufel; Houssam Boulenouar; Xavier Hermant; Nadhira Saidi-Mehtar; Philippe Amouyel; Leila Houti; Louisa Goumidi; Aline Meirhaeghe
Journal:  BMC Genet       Date:  2014-12-10       Impact factor: 2.797

8.  T2DM GWAS in the Lebanese population confirms the role of TCF7L2 and CDKAL1 in disease susceptibility.

Authors:  Michella Ghassibe-Sabbagh; Marc Haber; Angelique K Salloum; Yasser Al-Sarraj; Yasmine Akle; Kamal Hirbli; Jihane Romanos; Francis Mouzaya; Dominique Gauguier; Daniel E Platt; Hatem El-Shanti; Pierre A Zalloua
Journal:  Sci Rep       Date:  2014-12-08       Impact factor: 4.379
  8 in total

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