Qun Lu1, Gang Tian, Yong Zhang, Min Lu, Xuefeng Lin, Aiqun Ma. 1. Department of Cardiovascular Medicine, First Affiliated Hospital of Medical College, School of Medicine of Xi'an Jiaotong University, and Institute of Cardiovascular Channelopathy, Key Laboratory of Environment and Genes Related to Diseases (Xi'an Jiaotong University), the Ministry of Education, Key Laboratory of Molecular Cardiology, No. 277 Yanta West Road, Xi'an, Shaanxi Province 710061, PR China.
Abstract
BACKGROUND: High-density lipoprotein cholesterol (HDL-C) can predict the occurrence and prognosis of coronary heart disease (CHD) in the Western population; however, the role of HDL-C in Chinese populations is unclear. Thus, we investigated the predictive value of HDL-C on the risk and clinical outcomes of CHD in the Han Chinese population. METHODS: In a case-control study, plasma HDL-C levels of CHD patients and controls were evaluated to analyse the diagnostic value of HDL-C on CHD. In a prospective cohort study, the predictive value of HDL-C on the development of major adverse cardiovascular events (MACE) was determined in CHD patients who underwent a percutaneous coronary intervention (PCI). RESULTS: In the case-control study, HDL-C levels were significantly lower in patients with CHD (n = 375) compared to the controls (n = 328, P < 0.05). There were more male patients in the CHD group than in the control group. Logistic regression analysis showed that, relative to other lipid parameters, the relationship between HDL-C levels and CHD showed the strongest association. A stratified analysis showed that gender did not affect the relationship between HDL-C levels and CHD. The prospective cohort study found that in the low HDL-C subgroup of CHD patients (n = 249) who underwent PCI, 62 (24.9%) patients experienced a MACE during the 120-week follow-up period. However, only 15 (6.8%) patients experienced a MACE in the high HDL-C subgroup (n = 219; P < 0.05). Kaplan-Meier analysis revealed that the MACE rate and death rate were significantly higher in the low HDL-C subgroup than in their counterparts with high HDL-C levels (P < 0.05). The Cox regression analysis showed that HDL-C was an independent predictor of a MACE during the follow-up period (hazard ratio = 0.395, P = 0.005). CONCLUSIONS: Low HDL-C was the most powerful lipid parameter for predicting the risk and the clinical outcome of CHD in the Han Chinese population. Crown
BACKGROUND: High-density lipoprotein cholesterol (HDL-C) can predict the occurrence and prognosis of coronary heart disease (CHD) in the Western population; however, the role of HDL-C in Chinese populations is unclear. Thus, we investigated the predictive value of HDL-C on the risk and clinical outcomes of CHD in the Han Chinese population. METHODS: In a case-control study, plasma HDL-C levels of CHD patients and controls were evaluated to analyse the diagnostic value of HDL-C on CHD. In a prospective cohort study, the predictive value of HDL-C on the development of major adverse cardiovascular events (MACE) was determined in CHD patients who underwent a percutaneous coronary intervention (PCI). RESULTS: In the case-control study, HDL-C levels were significantly lower in patients with CHD (n = 375) compared to the controls (n = 328, P < 0.05). There were more male patients in the CHD group than in the control group. Logistic regression analysis showed that, relative to other lipid parameters, the relationship between HDL-C levels and CHD showed the strongest association. A stratified analysis showed that gender did not affect the relationship between HDL-C levels and CHD. The prospective cohort study found that in the low HDL-C subgroup of CHD patients (n = 249) who underwent PCI, 62 (24.9%) patients experienced a MACE during the 120-week follow-up period. However, only 15 (6.8%) patients experienced a MACE in the high HDL-C subgroup (n = 219; P < 0.05). Kaplan-Meier analysis revealed that the MACE rate and death rate were significantly higher in the low HDL-C subgroup than in their counterparts with high HDL-C levels (P < 0.05). The Cox regression analysis showed that HDL-C was an independent predictor of a MACE during the follow-up period (hazard ratio = 0.395, P = 0.005). CONCLUSIONS: Low HDL-C was the most powerful lipid parameter for predicting the risk and the clinical outcome of CHD in the Han Chinese population. Crown
Authors: Eujene Jung; So Yeon Kong; Young Sun Ro; Hyun Ho Ryu; Sang Do Shin Journal: Int J Environ Res Public Health Date: 2022-07-06 Impact factor: 4.614