| Literature DB >> 23105814 |
Maneesh Mailankot1, H Jayalekshmi, Amit Chakrabarti, D M Vasudevan.
Abstract
To investigate reversibility of ethanol induced testicular injuries on treatment with L-ornithine-L-aspartate, male Wistar rats were treated with ethanol (1.6g/kg b.wt/day) and L-ornithine- L-aspartate (200mg/kg b.wt/ day) for 4 weeks. L-ornithine-L-aspartate effectively prevented the ethanol induced body and testes weight reduction; changes in testicular weight well correlated with body weight. Drug exhibited an ability to counteract ethanol induced oxidative challenge as it effectively reduced testicular TBARS and increased tissue ascorbic acid, GSH and activities of superoxide dismutase, catalase, GSH-Red and Se-GSH-Px. However the drug didn't show promising effect on inhibitory effect of ethanol on testicular D5, 3-beta and 17-beta HSD (hydroxy steroid dehydrogenase).Entities:
Keywords: Ethanol; L-ornithine-L-aspartate treatment; Oxidative damage; Testicular injury
Year: 2009 PMID： 23105814 PMCID： PMC3453467 DOI： 10.1007/s12291-009-0016-z
Source DB: PubMed Journal: Indian J Clin Biochem ISSN： 0970-1915