Oxidative stress and serum α(1) - Antitrypsin in smokers.

The present study was undertaken to evaluate the levels of serum lipid peroxide, nitric oxide end poducts, erythrocytic superoxide dismutase activity and serum α(1)-antitrypsin in smokers. Total 90 active cigarette smokers were subdivided into Group I (subjects with smoking habit of less than 10 cigarettes per day) and Group II (with smoking habit of more than 10 cigarettes per day). In both groups lipid peroxide and nitric oxide end products were significantly increased with significantly decrease in erythrocytic superoxide dismutase activity and serum α(1)-antitrypsin as compared to controls. Our findings show enhanced oxidative stress and reduced α(1)-antitrypsin in cigarette smokers. Further increase in number of cigarettes per day exacerbates the oxidative stress with decrease in α(1)-antitrypsin.