Literature DB >> 23105751

Effect of irbesartan on streptozotocin induced diabetic nephropathy: An interventionary study.

Richa Vaishya1, Janardhan Singh, Harbans Lal.   

Abstract

Effect of irbesartan, an angiotensin II receptor antagonist, was studied in streptozotocin (STZ) induced diabetic nephropathy. Polyuria, proteinuria, blood urea, creatinine clearance, and urinary electrolytes were determined to assess kidney damage. There was a significant increase in urine volume, urinary protein and blood urea in STZ induced diabetic rats. On the other hand, irbesartan treatment resulted in a significant reduction in urinary protein and blood urea in these rats. Irbesartan treatment also improved creatinine clearance and exhibited a natriuretic effect in these animals. Results suggest that irbesartan treatment ameliorate STZ induced diabetic nephropathic changes, in rats.

Entities:  

Keywords:  Diabetic nephropathy; Irbesartan; Streptozotocin

Year:  2008        PMID： 23105751      PMCID： PMC3453087          DOI： 10.1007/s12291-008-0043-1

Source DB:  PubMed          Journal:  Indian J Clin Biochem        ISSN： 0970-1915


  5 in total

1.  Interaction between irbesartan, peroxisome proliferator-activated receptor (PPAR-γ), and adiponectin in the regulation of blood pressure and renal function in spontaneously hypertensive rats.

Authors:  S Afzal; M A Sattar; Edward J Johns; Mohammed H Abdulla; Safia Akhtar; Fayyaz Hashmi; Nor Azizan Abdullah
Journal:  J Physiol Biochem       Date:  2016-07-12       Impact factor: 4.158

2.  Renoprotective effect of lansoprazole in streptozotocin-induced diabetic nephropathy in wistar rats.

Authors:  Rupinder Kaur; Rupinder Kaur Sodhi; Neha Aggarwal; Jaspreet Kaur; Upendra K Jain
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2015-10-16       Impact factor: 3.000

3.  Involvement of vascular endothelial nitric oxide synthase in development of experimental diabetic nephropathy in rats.

Authors:  Atul Arya; Harlokesh Naryan Yadav; P L Sharma
Journal:  Mol Cell Biochem       Date:  2011-04-06       Impact factor: 3.396

4.  Design and optimization of crocetin loaded PLGA nanoparticles against diabetic nephropathy via suppression of inflammatory biomarkers: a formulation approach to preclinical study.

Authors:  Xiaodong Yang
Journal:  Drug Deliv       Date:  2019-12       Impact factor: 6.419

5.  Rosuvastatin Induces Renal HO-1 Activity and Expression Levels as a Main Protective Mechanism against STZ-Induced Diabetic Nephropathy.

Authors:  Gehan H Heeba; Marwa A M Ali; Azza A K El-Sheikh
Journal:  Medicina (Kaunas)       Date:  2022-03-15       Impact factor: 2.430
  5 in total

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