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Literature DB >> 23105662

Biochemical activity of selenium and glutathione on country made liquor (CML) induced hepatic damage in rats.

G Kumar¹, G Sharmila Banu, M Rajasekara Pandian.

Abstract

The serum and hepatic enzymes of rats were studied after exposed to country made liquor (CML) along with two chelating agents (glutathione and Selenium). There was a significant increase in several serum enzyme levels (viz., aspartate transaminase, alanine transaminase, alkaline phosphatase, sorbitol dehydrogenase, glutamate dehydrogenase, bilirubin) and decrease in various hepatic enzymes (Succinic dehydrogenase, Glucose 6-phosphatase, 5'Nucleotiease, Acid phosphatase, Acid ribonuclease, Cytochrome P-450) due to repeated administration of CML (2ml/100g of body weight). Results of this study revealed that the GSH and Se could give a significant protective action in serum and hepatic enzymes of CML exposed rats.

Entities: Chemical Disease Gene Species

Keywords: CML; Chelating agents; Hepatoprotection; Serum and Hepatic enzymes

Year: 2007 PMID： 23105662 PMCID： PMC3454273 DOI： 10.1007/BF02912891

Source DB: PubMed Journal: Indian J Clin Biochem ISSN： 0970-1915

13 in total

3. Protective Effect of Aqueous Extract from the Leaves of Justicia tranquebariesis against Thioacetamide-Induced Oxidative Stress and Hepatic Fibrosis in Rats.

Authors: Kumeshini Sukalingam; Kumar Ganesan; Baojun Xu
Journal: Antioxidants (Basel) Date: 2018-06-22

3 in total

Biochemical activity of selenium and glutathione on country made liquor (CML) induced hepatic damage in rats.

1. THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. I. EVIDENCE FOR ITS HEMOPROTEIN NATURE.

2. Studies on the terminal electron transport system. I. Succinic dehydrogenase.

3. A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases.

4. Tissue fractionation studies. 6. Intracellular distribution patterns of enzymes in rat-liver tissue.

5. Estimation of plasma phosphatase by determination of hydrolysed phenol with amino-antipyrine.

6. Risk factors for alcoholic liver disease.

7. Suppression of enzyme release from isolated rat liver lysosomes by non-steroidal anti-inflammatory drugs.

8. Interaction of alcohol and hepatitis C virus infection on severity of liver disease.

9. Antihepatotoxic effect of beta-carotene on paracetamol induced hepatic damage in rats.

10. Catalytic efficiency of human alcohol dehydrogenases for retinol oxidation and retinal reduction.

Review 1. Anti-Fungal Efficacy and Mechanisms of Flavonoids.

Review 2. Efficacy and Mechanisms of Flavonoids against the Emerging Opportunistic Nontuberculous Mycobacteria.

3. Protective Effect of Aqueous Extract from the Leaves of Justicia tranquebariesis against Thioacetamide-Induced Oxidative Stress and Hepatic Fibrosis in Rats.