Literature DB >> 23105576

Raised serum homocysteine levels in patients of coronary artery disease and the effect of vitamin B12 and folate on its concentration.

R Abraham1, M Joseph John, R Calton, J Dhanoa.   

Abstract

Homocysteine(Hcy) has been implicated as a novel risk factor of Coronary Artery Disease (CAD) among Asian Indians, but many studies done in India failed to reveal any direct correlation. It has also been reported that Folic acid and Vitamin B12 levels inversely affect serum levels of homocysteine. In this study, we looked at the levels of homocysteine among patients with CAD. The effect of Vitamin B12, Folate and other risk factors on homocysteine levels were also evaluated. Mean homocysteine levels in cases (22.81±13.9, n=70) were significantly higher (p=<0.001) than the controls (7.77±7.3, n=70). However no statistically significant correlation could be deduced between homocysteine Vitamin B12, and Folate. Cumulative analysis have indicated an increase in homocysteine levels among patients with CAD with every additional risk factor.

Entities:  

Keywords:  Coronary Artery Disease; Homocysteine

Year:  2006        PMID： 23105576      PMCID： PMC3453787          DOI： 10.1007/BF02913073

Source DB:  PubMed          Journal:  Indian J Clin Biochem        ISSN： 0970-1915


  27 in total

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Journal:  J Clin Invest       Date:  1976-04       Impact factor: 14.808

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Journal:  Br J Biomed Sci       Date:  1994-09       Impact factor: 3.829

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Authors:  M den Heijer; T Koster; H J Blom; G M Bos; E Briet; P H Reitsma; J P Vandenbroucke; F R Rosendaal
Journal:  N Engl J Med       Date:  1996-03-21       Impact factor: 91.245

8.  Hyperhomocysteinemia, and low intakes of folic acid and vitamin B12 in urban North India.

Authors:  Anoop Misra; Naval K Vikram; R M Pandey; Manjari Dwivedi; Faiz Uddin Ahmad; Kalpana Luthra; Kajal Jain; Nidhi Khanna; J Rama Devi; Rekha Sharma; Randeep Guleria
Journal:  Eur J Nutr       Date:  2002-04       Impact factor: 5.614

9.  Plasma homocyst(e)ine, folate, and vitamin B-12 concentrations and risk for early-onset coronary artery disease.

Authors:  N Pancharuniti; C A Lewis; H E Sauberlich; L L Perkins; R C Go; J O Alvarez; M Macaluso; R T Acton; R B Copeland; A L Cousins
Journal:  Am J Clin Nutr       Date:  1994-04       Impact factor: 7.045

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Authors:  L Brattström; A Lindgren; B Israelsson; A Andersson; B Hultberg
Journal:  J Intern Med       Date:  1994-12       Impact factor: 8.989
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  5 in total

1.  Correlation of serum homocysteine levels with the severity of coronary artery disease.

Authors:  Vijetha Shenoy; Veena Mehendale; Krishnananda Prabhu; Ranjan Shetty; Pragna Rao
Journal:  Indian J Clin Biochem       Date:  2013-08-31

2.  Low nourishment of B-vitamins is associated with hyperhomocysteinemia and oxidative stress in newly diagnosed cardiac patients.

Authors:  Mostafa I Waly; Amanat Ali; Amira Al-Nassri; Mohamed Al-Mukhaini; John Valliatte; Yahya Al-Farsi
Journal:  Exp Biol Med (Maywood)       Date:  2015-08-04

3.  Genetic interactions between MTHFR (C677T), methionine synthase (A2756G, C2758G) variants with vitamin B12 and folic acid determine susceptibility to premature coronary artery disease in Indian population.

Authors:  V V Ravi Kanth; Jaya Prakash Golla; B K S Sastry; Sudhir Naik; Nitin Kabra; Madireddi Sujatha
Journal:  J Cardiovasc Dis Res       Date:  2011-07

4.  Role of plasma homocysteine levels and other associated factors with coronary artery disease among Palestinian patients in North Palestine: a case control study.

Authors:  Issa Alawneh; Abulkareem Saymeh; Muath Daraghmeh; Dima Jabri; Liana Yaseen
Journal:  Pan Afr Med J       Date:  2022-07-06

5.  Hyperhomocysteinemia Predicts the Severity of Coronary Artery Disease as Determined by the SYNTAX Score in Patients with Acute Coronary Syndrome.

Authors:  Muhammed Karadeniz; Taner Sarak; Mustafa Duran; Caglar Alp; Huseyin Kandemir; İbrahim Etem Celik; Vedat Simsek; Alparslan Kılıc
Journal:  Acta Cardiol Sin       Date:  2018-11       Impact factor: 2.672
  5 in total

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