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Literature DB >> 23105517

Usefulness of serum CA 15.3 and histopathological prognostic indices in breast cancer.

R Nalini¹, C R Wilma Delphine Silvia, Purnima M Makhija, Sheila Uthappa.

Abstract

Prognostic factors influence the modality and course of therapy in breast cancer. These include both histopathological and biochemical variables. This study was aimed to find out if any correlation exists between the biochemical tumor marker-serum CA 15.3, and the lymph node staging of Nottingham's Prognostic Index (NPI). It was observed that serum CA 15.3 showed a statistically significant correlation with lymph node staging of NPI. Therefore it is concluded that CA 15.3 can be utilized as a useful prognostic marker, particularly in cases where histopathological variables such as tumor size and grade have been altered by pre-operative chemotherapy.

Entities: Disease

Keywords: Breast Cancer; CA 15.3; NPI; Nottingham’s Prognostic Index

Year: 2005 PMID： 23105517 PMCID： PMC3454159 DOI： 10.1007/BF02893065

Source DB: PubMed Journal: Indian J Clin Biochem ISSN： 0970-1915

13 in total

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Journal: Eur J Cancer Date: 2001-03 Impact factor: 9.162

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Authors: M H Galea; R W Blamey; C E Elston; I O Ellis
Journal: Breast Cancer Res Treat Date: 1992 Impact factor: 4.872

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Review 7. Biochemical markers in breast cancer: which ones are clinically useful?

Authors: M J Duffy
Journal: Clin Biochem Date: 2001-07 Impact factor: 3.281

8. High preoperative CA 15-3 concentrations predict adverse outcome in node-negative and node-positive breast cancer: study of 600 patients with histologically confirmed breast cancer.

Authors: Michael J Duffy; Catherine Duggan; Rachel Keane; Arnold D K Hill; Enda McDermott; John Crown; Niall O'Higgins
Journal: Clin Chem Date: 2004-01-15 Impact factor: 8.327

Usefulness of serum CA 15.3 and histopathological prognostic indices in breast cancer.

1. Prognostic factors in breast cancer: the predictive value of the Nottingham Prognostic Index in patients with a long-term follow-up that were treated in a single institution.

Review 2. Preoperative assessment of prognostic factors in breast cancer.

3. The Nottingham Prognostic Index in primary breast cancer.

4. Clinical and technical evaluation of ACS BR serum assay of MUC1 gene-derived glycoprotein in breast cancer, and comparison with CA 15-3 assays.

Review 5. ABC of breast diseases. Prognostic factors.

6. Prognostic factors in breast cancer -- the formation of a prognostic index.

Review 7. Biochemical markers in breast cancer: which ones are clinically useful?

8. High preoperative CA 15-3 concentrations predict adverse outcome in node-negative and node-positive breast cancer: study of 600 patients with histologically confirmed breast cancer.

9. TPS and CA 15.3 serum values as a guide for treating and monitoring breast cancer patients.

10. A prognostic index in primary breast cancer.

1. Correlation study of Carcino Embryonic Antigen & Cancer Antigen 15.3 in pretreated female breast cancer patients.

2. Tumour markers: An overview.

3. Thioredoxin system: a model for determining novel lead molecules for breast cancer chemotherapy.