Literature DB >> 23105506

Effect of spironolactone on acid and alkaline phosphatase in the testes of albino rat.

P K Singh1, D P Singh.   

Abstract

The biological activity of the mineralocorticoid antagonist, spironolactone depend upon its metabolism. In this study the effect of diuretic drug compound spironolactone on the acid and alkaline phosphatase in the testes of albino rat. The drug spironolactone was administered orally daily for 7(th), 14(th) and 21(st) days at the dose of 100 mg/kg body weight. Among them, the side effects of drug are that the degradation of alkaline phosphatase in the testes; while acid phosphatase increased significantly may be due to 7a-thiospironolactone is a tissue metabolite of spironolactone and may contribute to the testicular enzymes, therapeutic actions and some other side effects. It is suggested that the decrease and increase of alkaline and acid phosphatase in the testes of albino rat are the due to the side effects of spironolactone drug compound.

Entities:  

Keywords:  Acid and Alkaline Phosphatase; Albino rat; Drug Spironolactone

Year:  2005        PMID： 23105506      PMCID： PMC3454152          DOI： 10.1007/BF02893054

Source DB:  PubMed          Journal:  Indian J Clin Biochem        ISSN： 0970-1915


  10 in total

1.  Effect of spironolactone on sex hormones in man.

Authors:  B Stripp; A A Taylor; F C Bartter; J R Gillette; D L Loriaux; R Easley; R H Menard
Journal:  J Clin Endocrinol Metab       Date:  1975-10       Impact factor: 5.958

2.  A method for the determination of tartratelabile, prostatic acid phosphatase in serum.

Authors:  E J KING; K A JEGATHEESAN
Journal:  J Clin Pathol       Date:  1959-01       Impact factor: 3.411

3.  Estimation of plasma phosphatase by determination of hydrolysed phenol with amino-antipyrine.

Authors:  P R KIND; E J KING
Journal:  J Clin Pathol       Date:  1954-11       Impact factor: 3.411

Review 4.  Spironolactone.

Authors:  H R Ochs; D J Greenblatt; G Bodem; T W Smith
Journal:  Am Heart J       Date:  1978-09       Impact factor: 4.749

Review 5.  Secretions of the testis and epididymis.

Authors:  B P Setchell
Journal:  J Reprod Fertil       Date:  1974-03

6.  Spironolactone and testicular cytochrome P-450: decreased testosterone formation in several species and changes in hepatic drug metabolism.

Authors:  R H Menard; B Stripp; J R Gillette
Journal:  Endocrinology       Date:  1974-06       Impact factor: 4.736

7.  Anti-androgenic activity of spironolactone.

Authors:  S L Steelman; J R Brooks; E R Morgan; D J Patanelli
Journal:  Steroids       Date:  1969-10       Impact factor: 2.668

8.  The effect of spironolactone on the elemental composition of the intraluminal fluids of the seminiferous tubules, rete testis and epididymis of the rat.

Authors:  A D Jenkins; C P Lechene; S S Howards
Journal:  J Urol       Date:  1983-04       Impact factor: 7.450

9.  Effect of spironolactone on hepatic microsomal monooxygenase and azoreductase activities.

Authors:  S Fujita; T Uesugi; M Ohta; K Kitani
Journal:  Res Commun Chem Pathol Pharmacol       Date:  1982-04

10.  Identification of spironolactone metabolites in plasma and target organs of guinea pigs.

Authors:  L E Los; A B Coddington; H G Ramjit; H D Colby
Journal:  Drug Metab Dispos       Date:  1993 Nov-Dec       Impact factor: 3.922
  10 in total
  1 in total

1.  Analysis of spironolactone residues in industrial wastewater and in drug formulations by cathodic stripping voltammetry.

Authors:  M S El-Shahawi; A S Bashammakh; A A Al-Sibaai; E A Bahaidarah
Journal:  J Pharm Anal       Date:  2012-10-23
  1 in total

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