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Literature DB >> 23105495

Picrotoxin-induced convulsions and lysosomal function in the rat brain.

Munjal M Acharya¹, Surbhi H Khamesra, Surendra S Katyare.

Abstract

The effect of picrotoxin-induced convulsions on lysosomal function in rat brain were evaluated by measuring the free as well as total acid phosphatase, cathepsin D, acid ribonuclease (RNAse II) and acid deoxyribonuclease (DNAse II) activities. Following picrotoxin treatment the free RNAse II activity increased whereas the total activities of practically all the other enzymes decreased. Paradoxically, the cathepsin D activity, free as well the total was completely abolished. In case of all the enzymes the ratio of Total activity/Free activity decreased indicating increased lysosomal membrane fragility which could lead to process of neurodegeneration in the epileptic animals.

Entities: Chemical Disease Gene Species

Keywords: Convulsions; Epilepsy; Lysosomal enzymes; Lysosomal function; Picrotoxin

Year: 2005 PMID： 23105495 PMCID： PMC3454155 DOI： 10.1007/BF02893043

Source DB: PubMed Journal: Indian J Clin Biochem ISSN： 0970-1915

20 in total

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3 in total