Alteration in some antioxidant enzymes in cardiac tissue upon monosodium glutamate [MSG] administration to adult male mice.

4mg and 8mg monosodium glutamate per gram body weight was administered subcutaneously for 6 consecutive days to normal adult male mice and its effect was seen on 31(st) day after the last injection on some antioxidant enzymes in heart. A significant dose dependent increase in lipid peroxidation and xanthine oxidase level was observed, whereas the activity of free radical scavenging enzymes such as superoxide dismutase and catalase was decreased in both monosodium glutamate treated groups (Group-2 and Group-3). So, the present work suggested that monosodium glutamate at dose level of 4mg/g body weight and above induced oxidative stress in the cardiac tissue by changing the activity of free radical initiating enzyme such as xanthine oxidase and scavenging enzymes like superoxide dismutase and catalase.