Literature DB >> 23105476

Evaluation of microsatellite instability in tumors of central nervous system: A pilot study.

Minal Vaish1, Raj Kumar, R D Mittal, Balraj Mittal.   

Abstract

Microsatellite instability (MSI) characterized by alterations at simple repetitive genomic sequences is a distinct mechanism in tumorogenesis. Central nervous system (CNS) tumors have been reported to exhibit MSI, indicator of defective mismatch repair system with controversies. The present study was undertaken to examine sixteen primary brain and two spinal tumors for MSI at six mono: BAT-26, BAT-40, BAX, TGFßRII, IGFIIR and hMSH3 and four dinucleotide loci: D2S123, D9S1851, D9S283 and D18S58. Polymerase chain reaction (PCR) was done to amplify tumour and blood DNA, analyzed on 8% denaturing Polyacrylamide gel followed by autoradiography. Out of 18 CNS tumors examined, 39% exhibited MSI at BAT-26, BAT-40, D9S1851, D9S283 and D18S58 in tumoral DNA. However, no alteration was observed at BAX, TGFßRII, IGFIIR, hMSH3 and D2S123 loci. Low incidence of MS1-high hypothesizes role of MSI in evolution of CNS tumors but not in cancer initiation or progression.

Entities:  

Keywords:  Brain and spinal tumors; Mismatch repair; Mono-and dinucleotide microsatellite markers; Tumor development

Year:  2004        PMID： 23105476      PMCID： PMC3454185          DOI： 10.1007/BF02894277

Source DB:  PubMed          Journal:  Indian J Clin Biochem        ISSN： 0970-1915


  19 in total

1.  Allelic profiles of mononucleotide repeat microsatellites in control individuals and in colorectal tumors with and without replication errors.

Authors:  X P Zhou; J M Hoang; P Cottu; G Thomas; R Hamelin
Journal:  Oncogene       Date:  1997-10-02       Impact factor: 9.867

2.  Elevated c-myc expression in childhood medulloblastomas.

Authors:  D N MacGregor; E B Ziff
Journal:  Pediatr Res       Date:  1990-07       Impact factor: 3.756

3.  Microsatellite instability in colorectal cancer: different mutator phenotypes and the principal involvement of hMLH1.

Authors:  S N Thibodeau; A J French; J M Cunningham; D Tester; L J Burgart; P C Roche; S K McDonnell; D J Schaid; C W Vockley; V V Michels; G H Farr; M J O'Connell
Journal:  Cancer Res       Date:  1998-04-15       Impact factor: 12.701

4.  Microsatellite instability analysis of primary human brain tumors.

Authors:  J Zhu; S Z Guo; A H Beggs; T Maruyama; T Santarius; K Dashner; N Olsen; J K Wu; P Black
Journal:  Oncogene       Date:  1996-04-04       Impact factor: 9.867

5.  Microsatellite instability in human brain tumors.

Authors:  E van Meir; N de Tribolet
Journal:  Neurosurgery       Date:  1995-12       Impact factor: 4.654

6.  Acquisition of the glioblastoma phenotype during astrocytoma progression is associated with loss of heterozygosity on 10q25-qter.

Authors:  H Fujisawa; M Kurrer; R M Reis; Y Yonekawa; P Kleihues; H Ohgaki
Journal:  Am J Pathol       Date:  1999-08       Impact factor: 4.307

7.  Assessment of microsatellite instability in bladder and thyroid malignancies.

Authors:  Minal Vaish; S K Mishra; Anil Mandhani; R D Mittal; Balraj Mittal
Journal:  Teratog Carcinog Mutagen       Date:  2003

8.  Microsatellite instability in cancer of the proximal colon.

Authors:  S N Thibodeau; G Bren; D Schaid
Journal:  Science       Date:  1993-05-07       Impact factor: 47.728

9.  Identification of a microsatellite instability phenotype in meningiomas.

Authors:  M J Pykett; M Murphy; P R Harnish; D L George
Journal:  Cancer Res       Date:  1994-12-15       Impact factor: 12.701

Review 10.  Instability of microsatellites in human gliomas.

Authors:  E Dams; E J Van de Kelft; J J Martin; J Verlooy; P J Willems
Journal:  Cancer Res       Date:  1995-04-01       Impact factor: 12.701
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