Literature DB >> 23105230

Antibodies against free radical modified DNA in cancer patients.

A D Deepak1, S A Siddiqui, A Ali.   

Abstract

In this study we have modified DNA by exposing it to ultraviolet light in the presence of hydrogen peroxide. The modified DNA was probed for binding to the antibodies present in the sera of patients suffering from various types of cancer. Higher recognition of modified DNA, as compared to native DNA, by antibodies from cancer patients has got far reaching significance.

Entities:  

Keywords:  Cancer; DNA damage; Reactive oxygen species

Year:  2000        PMID： 23105230      PMCID： PMC3453546          DOI： 10.1007/BF02873540

Source DB:  PubMed          Journal:  Indian J Clin Biochem        ISSN： 0970-1915


  25 in total

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Authors:  K BURTON
Journal:  Biochem J       Date:  1956-02       Impact factor: 3.857

Review 2.  Oxidants and human disease: some new concepts.

Authors:  B Halliwell
Journal:  FASEB J       Date:  1987-11       Impact factor: 5.191

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Authors:  R Hasan; R Ali
Journal:  Biochem Int       Date:  1990

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Authors:  S Arjumand; A Ali
Journal:  Lupus       Date:  1998       Impact factor: 2.911

Review 5.  Genetic toxicology of oxygen.

Authors:  H Joenje
Journal:  Mutat Res       Date:  1989-07       Impact factor: 2.433

Review 6.  Genotoxicity of active oxygen species in mammalian cells.

Authors:  R Menghini
Journal:  Mutat Res       Date:  1988-05       Impact factor: 2.433

7.  Synergistic action of ultraviolet radiation and hydrogen peroxide on citrulline.

Authors:  A S Ansari; R Ali
Journal:  J Radiat Res       Date:  1984-12       Impact factor: 2.724

8.  Binding of monoclonal anti-native DNA autoantibodies to DNA of varying size and conformation.

Authors:  R Ali; H Dersimonian; B D Stollar
Journal:  Mol Immunol       Date:  1985-12       Impact factor: 4.407

Review 9.  DNA damage and oxygen radical toxicity.

Authors:  J A Imlay; S Linn
Journal:  Science       Date:  1988-06-03       Impact factor: 47.728

10.  Dimethyl sulfoxide prevents DNA nicking mediated by ionizing radiation or iron/hydrogen peroxide-generated hydroxyl radical.

Authors:  J E Repine; O W Pfenninger; D W Talmage; E M Berger; D E Pettijohn
Journal:  Proc Natl Acad Sci U S A       Date:  1981-02       Impact factor: 11.205
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