Current perspectives on laboratory markers for the assessment of cardiovascular disease and myocardial damage.

The disruption of the endothelim is a prelude to the evolution of arteriosclerosis. Nitric oxide is critical to endothelial function. The oxidation of low density lipoprotein (LDL) mediated by small dense LDL particles contributes to the development of cardiovascular disease. The multiple effects of homocysteine including its potentiating the binding of lipoprotein(a) (LP(a)) to fibrin and its role in the formation of small dense LDL particles highlights its importance in the evolution of cardiovascular disease and justifies its measurement. Problems in measurement of homocysteine should be kept in perspective. The measurement of release of proteins from the cardiac contractile apparatus such as Troponin I has advantages over conventional measurement of cardiac enzymes and isozymes.