Literature DB >> 2310385

14, 15-Epoxyeicosatrienoic acid promotes endothelial cell dependent adhesion of human monocytic tumor U937 cells.

K A Pritchard1, R R Tota, M B Stemerman, P Y Wong.   

Abstract

Arachidonic acid (AA) can be metabolized in endothelial cells (EC) to a series of epoxides via cytochrome P-450 epoxygenase with 14,15 epoxyeicosatrienoic acid (14,15-EET) as the major product. In this communication we report that 14,15-EET significantly enhances U937 cell attachment to EC with maximal cell attachment at 2.5 to 5 x 10(-7) M 14,15-EET. Thus, 14,15-EET may play a substantial role in inflammation and/or atherogenesis by inducing monocyte attachment to EC.

Entities:  

Mesh：

Substances：

Year:  1990        PMID： 2310385     DOI： 10.1016/0006-291x(90)91741-a

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  11 in total

1.  Spreading of HeLa cells on a collagen substratum requires a second messenger formed by the lipoxygenase metabolism of arachidonic acid released by collagen receptor clustering.

Authors:  J S Chun; B S Jacobson
Journal:  Mol Biol Cell       Date:  1992-05       Impact factor: 4.138

2.  11,12,20-Trihydroxy-eicosa-8(Z)-enoic acid: a selective inhibitor of 11,12-EET-induced relaxations of bovine coronary and rat mesenteric arteries.

Authors:  Ishfaq A Bukhari; Abdul Jabbar Shah; Kathryn M Gauthier; Katherine A Walsh; Sreenivasulu Reddy Koduru; John D Imig; John R Falck; William B Campbell
Journal:  Am J Physiol Heart Circ Physiol       Date:  2012-02-03       Impact factor: 4.733

3.  Cytochrome P450 monooxygenase lipid metabolites are significant second messengers in the resolution of choroidal neovascularization.

Authors:  Eiichi Hasegawa; Saori Inafuku; Lama Mulki; Yoko Okunuki; Ryoji Yanai; Kaylee E Smith; Clifford B Kim; Garrett Klokman; Diane R Bielenberg; Narender Puli; John R Falck; Deeba Husain; Joan W Miller; Matthew L Edin; Darryl C Zeldin; Kin Sing Stephen Lee; Bruce D Hammock; Wolf-Hagen Schunck; Kip M Connor
Journal:  Proc Natl Acad Sci U S A       Date:  2017-08-21       Impact factor: 11.205

Review 4.  Bisallylic hydroxylation and epoxidation of polyunsaturated fatty acids by cytochrome P450.

Authors:  E H Oliw; J Bylund; C Herman
Journal:  Lipids       Date:  1996-10       Impact factor: 1.880

5.  Evidence for mediation by endothelium-derived hyperpolarizing factor of relaxation to bradykinin in the bovine isolated coronary artery independently of voltage-operated Ca2+ channels.

Authors:  G R Drummond; T M Cocks
Journal:  Br J Pharmacol       Date:  1996-03       Impact factor: 8.739

Review 6.  Lipids in vascular function.

Authors:  A Sellmayer; N Hrboticky; P C Weber
Journal:  Lipids       Date:  1999       Impact factor: 1.880

7.  Atherogenic concentrations of low-density lipoprotein enhance endothelial cell generation of epoxyeicosatrienoic acid products.

Authors:  K A Pritchard; P Y Wong; M B Stemerman
Journal:  Am J Pathol       Date:  1990-06       Impact factor: 4.307

8.  11,12-Epoxyecosatrienoic acids mitigate endothelial dysfunction associated with estrogen loss and aging: Role of membrane depolarization.

Authors:  Chongxiu Sun; Scott I Simon; Greg A Foster; Christopher E Radecke; HyunTae V Hwang; Xiaodong Zhang; Bruce D Hammock; N Chiamvimonvat; Anne A Knowlton
Journal:  J Mol Cell Cardiol       Date:  2016-04-11       Impact factor: 5.000

Review 9.  Cytochrome P450 epoxygenases, soluble epoxide hydrolase, and the regulation of cardiovascular inflammation.

Authors:  Yangmei Deng; Katherine N Theken; Craig R Lee
Journal:  J Mol Cell Cardiol       Date:  2009-11-03       Impact factor: 5.000

10.  Anti-inflammatory effects of epoxyeicosatrienoic acids.

Authors:  Scott J Thomson; Ara Askari; David Bishop-Bailey
Journal:  Int J Vasc Med       Date:  2012-07-16
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.