| Literature DB >> 23103506 |
Pabyton G Cadena1, Marcela A Pereira, Rafaela B S Cordeiro, Isabella M F Cavalcanti, Benício Barros Neto, Maria do Carmo C B Pimentel, José Luiz Lima Filho, Valdinete L Silva, Nereide S Santos-Magalhães.
Abstract
Based on the fact that quercetin (QUE) and resveratrol (RES) induce a synergic inhibition of the adipogenesis and increase apoptosis in adipocytes, and that sodium deoxycholate (SDC) has necrotic effects, the nanoencapsulation of QUE and RES into SDC-elastic liposomes is proposed as a new approach for dissolving the subcutaneous fat. The concentration of constituents and the effect of the drug incorporation into cyclodextrin inclusion complexes on the stability of QUE/RES-loaded liposomes were studied. The best liposomal formulation reduced the use of phosphatidylcholine and cholesterol in 17.7% and 68.4%, respectively. Liposomes presented a mean diameter of 149nm with a polydispersion index of 0.3. The zeta potential of liposomes was slightly negative (-13.3mV) due to the presence of SDC in the phospholipid bilayer. Encapsulation efficiency of QUE and RES into liposomes was almost 97%. To summarize, QUE/RES-loaded elastic liposomes are stable and suitable for subcutaneous injection, thereby providing a new strategy for reducing subcutaneous fat.Entities:
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Year: 2012 PMID： 23103506 DOI： 10.1016/j.bbamem.2012.10.022
Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002