| Literature DB >> 23103228 |
Hong Liu1, Astrid Irwanto, Hongqing Tian, Xi'an Fu, Yongxiang Yu, Gongqi Yu, Huiqi Low, Tongsheng Chu, Yi Li, Benqing Shi, Mingfei Chen, Yonghu Sun, Chunying Yuan, Nan Lu, Jiabao You, Fangfang Bao, Jinghui Li, Jian Liu, Huaxu Liu, Dianchang Liu, Xiulu Yu, Lin Zhang, Qing Yang, Na Wang, Guiye Niu, Shanshan Ma, Yan Zhou, Chuan Wang, Shumin Chen, Xuejun Zhang, Jianjun Liu, Furen Zhang.
Abstract
Of eight leprosy susceptibility loci identified by genome-wide association studies, five have been implicated in Crohn disease, suggesting a common genetic fingerprint between leprosy and inflammatory bowel disease (IBD). Here, we conducted a multiple-stage genetic association study of 133 IBD susceptibility loci in multiple leprosy samples (totaling 4,971 leprosy cases and 5,503 controls) from a Chinese population and discovered two associations at rs2058660 on 2q12.1 (p = 4.57 × 10(-19); odds ratio [OR] = 1.30) and rs6871626 on 5q33.3 (p = 3.95 × 10(-18); OR = 0.75), implicating IL18RAP/IL18R1 and IL12B as susceptibility genes for leprosy. Our study reveals the important role of IL12/IL18-mediated transcriptional regulation of IFN-γ production in leprosy, and together with previous findings, it demonstrates the shared genetic susceptibility between infectious and inflammatory diseases.Entities:
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Year: 2012 PMID： 23103228 PMCID： PMC3487119 DOI： 10.1016/j.ajhg.2012.09.010
Source DB: PubMed Journal: Am J Hum Genet ISSN： 0002-9297 Impact factor: 11.025