| Literature DB >> 23102891 |
Letizia Giampietro1, Alessandra D'Angelo, Antonella Giancristofaro, Alessandra Ammazzalorso, Barbara De Filippis, Marialuigia Fantacuzzi, Pasquale Linciano, Cristina Maccallini, Rosa Amoroso.
Abstract
In an effort to develop safe and efficacious compounds for the treatment of metabolic disorders, new compounds based on a combination of clofibric acid, the active metabolite of clofibrate, and lipophilic groups derived from natural products chalcone and stilbene were synthesised. Some of them were found to be active at micromolar concentrations only on PPARα or PPARγ, while others were identified as dual agonists PPARα/γ.Entities:
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Year: 2012 PMID： 23102891 DOI： 10.1016/j.bmcl.2012.09.111
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823