| Literature DB >> 23102693 |
Ming Li1, Yi Wang, Xue-bin Zheng, Masashi Ikeda, Nakao Iwata, Xiong-jian Luo, Siow-Ann Chong, Jimmy Lee, Marcella Rietschel, Fengyu Zhang, Bertram Müller-Myhsok, Sven Cichon, Daniel R Weinberger, Manuel Mattheisen, Thomas G Schulze, Nicholas G Martin, Philip B Mitchell, Peter R Schofield, Jian-jun Liu, Bing Su.
Abstract
Recent genome-wide association studies have reported a set of schizophrenia susceptibility genes, but many of them await further replications in additional samples. Here we analyzed 5 genome-wide supported variants in a Han Chinese sample, and the variant rs2312147 at VRK2 showed significant association, which was confirmed in the meta-analysis combining multiple Asian and European samples (P=3.17×10(-4), N=7498). Rs2312147 is also associated with brain structure in healthy subjects, including the total brain volume and the white matter volume. Gene expression analyses indicated an up-regulation of VRK2 in schizophrenia patients. Our data provide further evidence for the contribution of VRK2 to schizophrenia.Entities:
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Year: 2012 PMID： 23102693 DOI： 10.1016/j.schres.2012.10.008
Source DB: PubMed Journal: Schizophr Res ISSN： 0920-9964 Impact factor: 4.939