PURPOSE: A simple test that could guide successful cessation of continuous renal replacement therapy (CRRT) in critically ill patients would be clinically useful. This study aimed to investigate whether a 2-hour creatinine clearance (2h-CrCl) measurement could more accurately predict successful cessation of CRRT than serum creatinine or urine output alone. MATERIALS AND METHODS: This retrospective study identified all patients admitted to a university teaching hospital intensive care unit who received CRRT and had a 2h-CrCl measurement performed in the 12 hours preceding CRRT cessation. The ability of 2h-CrCl to predict successful discontinuation of CRRT was compared to other renal indices. RESULTS: Of 85 patients who had 2h-CrCl performed prior to CRRT cessation 53 (62.4%)(success group) remained dialysis free 7 days after CRRT cessation. 2h-CrCl was a better predictor of remaining CRRT free at day 7 (OR, 1.108 [1.05-1.17] per 1 mL/min increase in 2 hours CrCl, P < .001) than urine output, serum creatinine or age. A 2h-CrCl value of 23 mL/min had a sensitivity, specificity and positive predictive value for remaining CRRT free at day 7 of 75.5%, 84.4%, and 88.8%, respectively. CONCLUSION: 2h-CrCl may be a useful measurement to help guide discontinuation from CRRT.
PURPOSE: A simple test that could guide successful cessation of continuous renal replacement therapy (CRRT) in critically illpatients would be clinically useful. This study aimed to investigate whether a 2-hour creatinine clearance (2h-CrCl) measurement could more accurately predict successful cessation of CRRT than serum creatinine or urine output alone. MATERIALS AND METHODS: This retrospective study identified all patients admitted to a university teaching hospital intensive care unit who received CRRT and had a 2h-CrCl measurement performed in the 12 hours preceding CRRT cessation. The ability of 2h-CrCl to predict successful discontinuation of CRRT was compared to other renal indices. RESULTS: Of 85 patients who had 2h-CrCl performed prior to CRRT cessation 53 (62.4%)(success group) remained dialysis free 7 days after CRRT cessation. 2h-CrCl was a better predictor of remaining CRRT free at day 7 (OR, 1.108 [1.05-1.17] per 1 mL/min increase in 2 hours CrCl, P < .001) than urine output, serum creatinine or age. A 2h-CrCl value of 23 mL/min had a sensitivity, specificity and positive predictive value for remaining CRRT free at day 7 of 75.5%, 84.4%, and 88.8%, respectively. CONCLUSION:2h-CrCl may be a useful measurement to help guide discontinuation from CRRT.
Authors: Sean M Bagshaw; Michael Darmon; Marlies Ostermann; Fredric O Finkelstein; Ron Wald; Ashita J Tolwani; Stuart L Goldstein; David J Gattas; Shigehiko Uchino; Eric A Hoste; Stephane Gaudry Journal: Intensive Care Med Date: 2017-03-13 Impact factor: 17.440
Authors: Susanne Stads; K Merijn Kant; Margriet F C de Jong; Wouter de Ruijter; Christa M Cobbaert; Michiel G H Betjes; Diederik Gommers; Heleen M Oudemans-van Straaten Journal: Blood Purif Date: 2019-07-22 Impact factor: 2.614
Authors: Julien Aniort; Ali Ait Hssain; Bruno Pereira; Elisabeth Coupez; Pierre Antoine Pioche; Christophe Leroy; Anne Elisabeth Heng; Bertrand Souweine; Alexandre Lautrette Journal: Crit Care Date: 2016-02-19 Impact factor: 9.097
Authors: Susanne Stads; K Merijn Kant; Margriet F C de Jong; Wouter de Ruijter; Christa M Cobbaert; Michiel G H Betjes; Diederik Gommers; Heleen M Oudemans-van Straaten Journal: BMC Nephrol Date: 2019-04-15 Impact factor: 2.388
Authors: Nicolas Viallet; Vincent Brunot; Nils Kuster; Delphine Daubin; Noémie Besnard; Laura Platon; Aurèle Buzançais; Romaric Larcher; Olivier Jonquet; Kada Klouche Journal: Ann Intensive Care Date: 2016-07-22 Impact factor: 6.925