PURPOSE: The Surviving Sepsis Guidelines established recommendations for early recognition and rapid treatment of patients with sepsis. Recognizing systemic difficulties that delayed the application of early goal-directed therapy, the Emergency Department and Critical Care leadership instituted a sepsis protocol to identify patients with sepsis and expedite antibiotic delivery. We aimed to determine if the sepsis protocol improved the time to first dose of antibiotics in patients diagnosed with sepsis. MATERIALS AND METHODS: We performed a retrospective chart review of patients with sepsis comparing the time from antibiotic order placement to the first dose of antibiotic therapy over a 3-year period. Patients who received vancomycin and ciprofloxacin underwent additional subgroup analysis, as these antibiotics were made available by protocol for use without infectious disease consultation. RESULTS: The average time to first dose of antibiotics for the presepsis protocol group was 160 minutes, and the average time for the sepsis protocol group was 99 minutes. Fifty-eight patients received vancomycin, and 30 received ciprofloxacin, with a decrease in time of 65 minutes and 41 minutes, respectively. CONCLUSIONS: Initiation of a sepsis protocol, which emphasizes early goal-directed therapy, can improve time to administration of first dose of antibiotics. Published by Elsevier Inc.
PURPOSE: The Surviving Sepsis Guidelines established recommendations for early recognition and rapid treatment of patients with sepsis. Recognizing systemic difficulties that delayed the application of early goal-directed therapy, the Emergency Department and Critical Care leadership instituted a sepsis protocol to identify patients with sepsis and expedite antibiotic delivery. We aimed to determine if the sepsis protocol improved the time to first dose of antibiotics in patients diagnosed with sepsis. MATERIALS AND METHODS: We performed a retrospective chart review of patients with sepsis comparing the time from antibiotic order placement to the first dose of antibiotic therapy over a 3-year period. Patients who received vancomycin and ciprofloxacin underwent additional subgroup analysis, as these antibiotics were made available by protocol for use without infectious disease consultation. RESULTS: The average time to first dose of antibiotics for the presepsis protocol group was 160 minutes, and the average time for the sepsis protocol group was 99 minutes. Fifty-eight patients received vancomycin, and 30 received ciprofloxacin, with a decrease in time of 65 minutes and 41 minutes, respectively. CONCLUSIONS: Initiation of a sepsis protocol, which emphasizes early goal-directed therapy, can improve time to administration of first dose of antibiotics. Published by Elsevier Inc.
Authors: Frank Bloos; Hendrik Rüddel; Daniel Thomas-Rüddel; Daniel Schwarzkopf; Christine Pausch; Stephan Harbarth; Torsten Schreiber; Matthias Gründling; John Marshall; Philipp Simon; Mitchell M Levy; Manfred Weiss; Andreas Weyland; Herwig Gerlach; Tobias Schürholz; Christoph Engel; Claudia Matthäus-Krämer; Christian Scheer; Friedhelm Bach; Reimer Riessen; Bernhard Poidinger; Karin Dey; Norbert Weiler; Andreas Meier-Hellmann; Helene H Häberle; Gabriele Wöbker; Udo X Kaisers; Konrad Reinhart Journal: Intensive Care Med Date: 2017-05-02 Impact factor: 17.440
Authors: Scott L Weiss; Julie C Fitzgerald; Fran Balamuth; Elizabeth R Alpern; Jane Lavelle; Marianne Chilutti; Robert Grundmeier; Vinay M Nadkarni; Neal J Thomas Journal: Crit Care Med Date: 2014-11 Impact factor: 7.598
Authors: Yana Puckett; Kelly Zhang; Jay Blasingame; Jessica Lorenzana; Shamini Parameswaran; Steven E Brooks Md Facs; Benedicto C Baronia; John Griswold Journal: Cureus Date: 2018-07-03