OBJECTIVE: To investigate the association of polymorphisms in the vascular endothelial growth factor (VEGF) family genes (VEGFA rs699947, VEGFA rs3025039, PGF rs1042886, KDR rs2071559 and KDR rs2305948) with preeclampsia in Sinhalese women in Sri-Lanka. METHODS: We conducted a case-control study where 175 nulliparous Sinhalese women with preeclampsia and 171 normotensive women matched for age, ethnicity, parity and BMI were recruited in tertiary care maternity hospitals in Sri-Lanka. Preeclampsia was diagnosed using international guidelines. DNA extracted from peripheral venous blood and was genotyped using the Sequenom MassARRAY system. χ(2)-test was used to compare the distribution of allele and genotype frequencies between the cases and the control subjects. RESULTS: The frequency of PGF rs1042886 variant allele (odds ratio (OR) 1.5, 95% confidence interval (CI) 1.1-2.1) and dominant genotype model (aOR 1.6, 95% CI 1.0-2.4) were increased in preeclamptic women compared to controls. VEGFA rs699947, VEGFA rs3025039, KDR rs2071559, and KDR rs2305948 polymorphisms were not associated with preeclampsia. CONCLUSION: Maternal PGF rs1042886 polymorphism is associated with preeclampsia in Sinhalese women in Sri-Lanka.
OBJECTIVE: To investigate the association of polymorphisms in the vascular endothelial growth factor (VEGF) family genes (VEGFArs699947, VEGFArs3025039, PGFrs1042886, KDRrs2071559 and KDRrs2305948) with preeclampsia in Sinhalesewomen in Sri-Lanka. METHODS: We conducted a case-control study where 175 nulliparous Sinhalesewomen with preeclampsia and 171 normotensive women matched for age, ethnicity, parity and BMI were recruited in tertiary care maternity hospitals in Sri-Lanka. Preeclampsia was diagnosed using international guidelines. DNA extracted from peripheral venous blood and was genotyped using the Sequenom MassARRAY system. χ(2)-test was used to compare the distribution of allele and genotype frequencies between the cases and the control subjects. RESULTS: The frequency of PGFrs1042886 variant allele (odds ratio (OR) 1.5, 95% confidence interval (CI) 1.1-2.1) and dominant genotype model (aOR 1.6, 95% CI 1.0-2.4) were increased in preeclamptic women compared to controls. VEGFArs699947, VEGFArs3025039, KDRrs2071559, and KDRrs2305948 polymorphisms were not associated with preeclampsia. CONCLUSION: Maternal PGFrs1042886 polymorphism is associated with preeclampsia in Sinhalesewomen in Sri-Lanka.
Authors: Melissa D Amosco; Van Anthony M Villar; Justin Michael A Naniong; Lara Marie G David-Bustamante; Pedro A Jose; Cynthia P Palmes-Saloma Journal: Clin Exp Hypertens Date: 2016-09-26 Impact factor: 1.749
Authors: Feriha Fatima Khidri; Yar Muhammad Waryah; Faiza Kamran Ali; Hina Shaikh; Ikram Din Ujjan; Ali Muhammad Waryah Journal: BMC Med Genet Date: 2019-10-23 Impact factor: 2.103
Authors: Hameed M Hamid; Sana E Abdalla; Mohamed Sidig; Ishag Adam; Hamdan Z Hamdan Journal: Mol Genet Genomic Med Date: 2020-01-14 Impact factor: 2.183