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Literature DB >> 23102214

Controlling radicals in the powerhouse: development of MitoSOD.

Tanecia Mitchell, Balu K Chacko, Victor Darley-Usmar.

Abstract

Investigators in the redox biology field have long recognized the unique role mitochondrial superoxide generation plays in physiological signaling and in dysregulated bioenergetic dysfunction. Pharmacological manipulation has been challenging, and in this issue of Chemistry & Biology, Kelso and colleagues present the synthesis and characterization of a novel mitochondrial-targeted SOD mimetic, MitoSOD.

Entities: Chemical Disease Gene Species

Year: 2012 PMID： 23102214 PMCID： PMC3491654 DOI： 10.1016/j.chembiol.2012.10.004

Source DB: PubMed Journal: Chem Biol ISSN： 1074-5521

12 in total

Review 1. Invited review: manganese superoxide dismutase in disease.

Authors: L A Macmillan-Crow; D L Cruthirds
Journal: Free Radic Res Date: 2001-04

Review 2. Mitochondrial energetics and therapeutics.

Authors: Douglas C Wallace; Weiwei Fan; Vincent Procaccio
Journal: Annu Rev Pathol Date: 2010 Impact factor: 23.472

Review 3. Targeting lipophilic cations to mitochondria.

Authors: Michael P Murphy
Journal: Biochim Biophys Acta Date: 2008-04-08

4. Hypothesis: the mitochondrial NO(*) signaling pathway, and the transduction of nitrosative to oxidative cell signals: an alternative function for cytochrome C oxidase.

Authors: Paul Brookes; Victor M Darley-Usmar
Journal: Free Radic Biol Med Date: 2002-02-15 Impact factor: 7.376

5. Pharmacological manipulation of the inflammatory cascade by the superoxide dismutase mimetic, M40403.

Authors: D Salvemini; E Mazzon; L Dugo; D P Riley; I Serraino; A P Caputi; S Cuzzocrea
Journal: Br J Pharmacol Date: 2001-02 Impact factor: 8.739

6. The mitochondria-targeted antioxidant mitoquinone protects against cold storage injury of renal tubular cells and rat kidneys.

Authors: Tanecia Mitchell; Dumitru Rotaru; Hamida Saba; Robin A J Smith; Michael P Murphy; Lee Ann MacMillan-Crow
Journal: J Pharmacol Exp Ther Date: 2010-12-15 Impact factor: 4.030

7. Pulse radiolysis investigation on the mechanism of the catalytic action of Mn(II)-pentaazamacrocycle compounds as superoxide dismutase mimetics.

Authors: Andrej Maroz; Geoffrey F Kelso; Robin A J Smith; David C Ware; Robert F Anderson
Journal: J Phys Chem A Date: 2008-05-13 Impact factor: 2.781

8. Mitochondria-targeted ubiquinone (MitoQ) decreases ethanol-dependent micro and macro hepatosteatosis.

Authors: Balu K Chacko; Anup Srivastava; Michelle S Johnson; Gloria A Benavides; Mi Jung Chang; Yaozu Ye; Nirag Jhala; Michael P Murphy; Balaraman Kalyanaraman; Victor M Darley-Usmar
Journal: Hepatology Date: 2011-07 Impact factor: 17.425

9. Prevention of diabetic nephropathy in Ins2(+/)⁻(AkitaJ) mice by the mitochondria-targeted therapy MitoQ.

Authors: Balu K Chacko; Colin Reily; Anup Srivastava; Michelle S Johnson; Yaozu Ye; Elena Ulasova; Anupam Agarwal; Kurt R Zinn; Michael P Murphy; Balaraman Kalyanaraman; Victor Darley-Usmar
Journal: Biochem J Date: 2010-11-15 Impact factor: 3.857

10. A mitochondria-targeted macrocyclic Mn(II) superoxide dismutase mimetic.

Authors: Geoffrey F Kelso; Andrej Maroz; Helena M Cochemé; Angela Logan; Tracy A Prime; Alexander V Peskin; Christine C Winterbourn; Andrew M James; Meredith F Ross; Sally Brooker; Carolyn M Porteous; Robert F Anderson; Michael P Murphy; Robin A J Smith
Journal: Chem Biol Date: 2012-10-26

1 in total

1. A non-toxic fluorogenic dye for mitochondria labeling.

Authors: Junyan Han; Myung Shin Han; Ching-Hsuan Tung
Journal: Biochim Biophys Acta Date: 2013-07-12

1 in total